最新一期《美國腸胃病學雜志》（American Journal of Gastroenterology）公布的一份研究報告說,，美國食道癌患者數(shù)量近年來急劇增加,，肥胖是主要原因之一，因此避免肥胖有助于預防食道癌,。
報告說,，從1973年至2001年,，美國的食道癌患者人數(shù)由30萬人增加至210萬人。盡管確切原因尚待進一步探討,，但研究顯示,，高脂肪、高糖飲食的過量攝取和因此導致的肥胖癥,，是誘發(fā)食道癌的主要因素之一,。
報告指出，食道癌是人類常見的惡性腫瘤之一,，治愈率較低,。在美國，食道癌患者術后5年存活率不到20%,。為了更好地預防食道癌,，專家建議人們應該改掉不良飲食習慣，少食用高脂肪和高糖食品,，增加運動，避免肥胖,。（來源：新華網(wǎng) 高原）
生物谷推薦原始出處:
（American Journal of Gastroenterology）,，Volume 103 Issue 2 Page 292，Michael B. Cook,，David Forman
A Systematic Review and Meta-Analysis of the Riskof Increasing Adiposity on Barrett's Esophagus
Michael B. Cook, B.Sc., Ph.D. , Darren C. Greenwood, B.Sc., M.Sc. , Laura J. Hardie, B.Sc., Ph.D. , Christopher P. Wild, B.Sc., Ph.D. 1, and David Forman, B.A., Ph.D.
OBJECTIVES: Esophageal adenocarcinoma and its precursor lesion, Barrett's esophagus, are increasing in incidence in western populations. Gastroesophageal reflux disease (GERD) and high body mass index (BMI) are known risk factors, but it is unclear whether BMI mediates its risk on Barrett's esophagus independently. This systematic review and meta-analysis investigated whether increasing BMI is associated with Barrett's esophagus as compared to general population and GERD controls.
METHODS: Search strategies were conducted in MEDLINE (U.S. National Library of Medicine, Bethesda, MD) (1966–2005) and EMBASE (Reed Elsevier PLC, Amsterdam, The Netherlands) (1980–2005). Studies to be included were required to present “current” BMI data for consecutively recruited Barrett's esophagus patients and appropriate comparison arms with a minimum number of 30 subjects in each.
RESULTS: The literature search produced 5,501 hits from which 295 papers were extracted. Only 10 studies met the criteria for inclusion. The Statistics/Data Analysis (STATA) program was used to conduct random effects meta-analyses. Nine studies comparing the BMI of the Barrett's esophagus and GERD groups produced a pooled odds ratio (OR) of 0.99 per kg/m2 (95% confidence interval [CI] 0.97–1.01, I2 = 52%), while the pooled estimate of three studies comparing Barrett's esophagus with general population controls was 1.02 per kg/m2 (95% CI 1.01–1.04, I2 = 0%).
CONCLUSIONS: Increasing adiposity is only an indirect risk factor of Barrett's esophagus through the precursor lesion of GERD. Hence, BMI status has no predictive value with respect to GERD patients and their risk of progression to Barrett's esophagus.
