生物谷報(bào)道：美國西北大學(xué)研究人員發(fā)現(xiàn)，大豆中含有一種叫三羥基異黃酮的抗氧化劑幾乎能完全遏制前列腺癌細(xì)胞在老鼠體內(nèi)擴(kuò)散。
美國癌癥研究協(xié)會(huì)出版的最新一期《癌癥研究》上刊登的一篇文章說,，美國西北大學(xué)研究人員在老鼠身上進(jìn)行的實(shí)驗(yàn)顯示，服用三羥基異黃酮的老鼠前列腺癌細(xì)胞轉(zhuǎn)移到肺
部的幾率減少了９６％。實(shí)驗(yàn)中使用的三羥基異黃酮含量也就相當(dāng)于人從一頓富含豆制品的飲食中攝取的量。
西北大學(xué)羅伯特·盧里綜合癌癥中心的雷蒙德·伯根說：“這些實(shí)驗(yàn)結(jié)果給了我們新的希望,，在阻止前列腺癌細(xì)胞擴(kuò)散方面，三羥基異黃酮或許能產(chǎn)生一定效果,。”
研究人員發(fā)現(xiàn),，雖然三羥基異黃酮不會(huì)使前列腺腫瘤變小，但它幾乎能完全阻止前列腺癌細(xì)胞轉(zhuǎn)移到肺部,。
生物谷推薦原始出處：
（Cancer Research）,，68, 2024-2032，Minalini Lakshman,，Raymond C. Bergan
etary Genistein Inhibits Metastasis of Human Prostate Cancer in Mice
Minalini Lakshman1, Li Xu1, Vijayalakshmi Ananthanarayanan2, Joshua Cooper4, Chris H. Takimoto4, Irene Helenowski2, Jill C. Pelling3 and Raymond C. Bergan1
1 Division of Hematology/Oncology, Department of Medicine, 2 Department of Preventive Medicine, and 3 Department of Pathology, Northwestern University Medical School and Robert H. Lurie Cancer Center of Northwestern University, Chicago, Illinois and 4 Institute for Drug Development, San Antonio, Texas
Requests for reprints: Raymond C. Bergan, Olson 8321, 710 North Fairbanks, Chicago, IL 60611-3008. Phone: 312-908-5284; Fax: 312-503-4744; E-mail: [email protected] .
Key Words: chemoprevention • prostate cancer • soy • metastasis • mouse model
Dietary genistein has been linked to lower prostate cancer (PCa) mortality. Metastasis is the ultimate cause of death from PCa. Cell detachment and invasion represent early steps in the metastatic cascade. We had shown that genistein inhibits PCa cell detachment and cell invasion in vitro. Genistein-mediated inhibition of activation of focal adhesion kinase (FAK) and of the p38 mitogen-activated protein kinase (MAPK)–heat shock protein 27 (HSP27) pathway has been shown by us to regulate PCa cell detachment and invasion effects, respectively. To evaluate the antimetastatic potential of genistein, we developed an animal model suited to evaluating antimetastatic drug efficacy. Orthotopically implanted human PC3-M PCa cells formed lung micrometastasis by 4 weeks in >80% of inbred athymic mice. Feeding mice dietary genistein before implantation led to blood concentrations similar to those measured in genistein-consuming men. Genistein decreased metastases by 96%, induced nuclear morphometric changes in PC3-M cells indicative of increased adhesion (i.e., decreased detachment) but did not alter tumor growth. Genistein increased tumor levels of FAK, p38 MAPK, and HSP27 "promotility" proteins. However, the ratio of phosphorylated to total protein trended downward, indicating a failure to increase relative amounts of activated protein. This study describes a murine model of human PCa metastasis well suited for testing antimetastatic drugs. It shows for the first time that dietary concentrations of genistein can inhibit PCa cell metastasis. Increases in promotility proteins support the notion of cellular compensatory responses to antimotility effects induced by therapy. Studies of antimetastatic efficacy in man are warranted and are under way. [Cancer Res 2008;68(6):2024–32]
