生物谷報道，德國癌癥研究中心（DKFZ）對中藥的76種植物進行研究,，至今共發(fā)現(xiàn)18種成份對癌細胞的生長有抑制作用,，這18種成份目前尚處于實驗室研究階段。研究中心以生物學(xué)家Thomas Efferth為首的研究小組的第一批研究結(jié)果已在癌癥研究權(quán)威雜志《分子癌癥研究》（Molecular Cancer Therapy,7/1,，2008）上發(fā)表,。此外，Efferth與Erlangen大學(xué)的研究人員一起對青蒿素的衍生物--青蒿琥酯進行研究,，并將一年生的青蒿應(yīng)用于兩名患眼內(nèi)血管膜瘤的患者身上,。一般得這種病的患者只能存活3至5個月，而服用含青蒿琥酯的試驗藥品后,，其中一人治療后活了兩年，另一名患者至今已活了4年,，并且已痊愈,。雖然這一結(jié)果不排除偶然可能，但它的成功極大鼓舞了對青蒿素的深入研究,。此外,，美國加利福尼亞大學(xué)伯克利分校還對姜黃屬植物進行研究，證明姜黃屬藥品能提高腸癌和肺癌病人化療的效果,。美國食品藥物管理局也批準了一項針對薏苡屬藥品治療肺癌作用的研究,。
生物谷推薦原始出處：
Molecular Cancer Therapeutics 7, 152-161, January 1, 2008. doi: 10.1158/1535-7163.MCT-07-0073
Phytochemistry and pharmacogenomics of natural products derived from traditional chinese medicine and chinese materia medica with activity against tumor cells
Thomas Efferth1, Stefan Kahl2,3,6, Kerstin Paulus4, Michael Adams2, Rolf Rauh5, Herbert Boechzelt3, Xiaojiang Hao6, Bernd Kaina5 and Rudolf Bauer2
1 German Cancer Research Centre, Pharmaceutical Biology, Heidelberg, Germany; 2 Institute of Pharmaceutical Sciences, University of Graz; 3 Joanneum Research, Graz, Austria; 4 Institute of Pharmaceutical Biology, University of Düsseldorf, Düsseldorf, Germany; 5 Institute of Toxicology, University of Mainz, Mainz, Germany; and 6 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
Requests for reprints: Thomas Efferth, German Cancer Research Centre, Pharmaceutical Biology (C015), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Phone: 49-6221-423426; Fax: 49-6221-423433.
Abstract
The cure from cancer is still not a reality for all patients, which is mainly due to the limitations of chemotherapy (e.g., drug resistance and toxicity). Apart from the high-throughput screening of synthetic chemical libraries, natural products represent attractive alternatives for drug development. We have done a systematic bioactivity-based screening of natural products derived from medicinal plants used in traditional Chinese medicine. Plant extracts with growth-inhibitory activity against tumor cells have been fractionated by chromatographic techniques. We have isolated the bioactive compounds and elucidated the chemical structures by nuclear magnetic resonance and mass spectrometry. By this strategy, we identified 25-O-acetyl-23,24-dihydro-cucurbitacin F as a cytotoxic constituent of Quisqualis indica. Another promising compound identified by this approach was miltirone from Salvia miltiorrhiza. The IC50 values for miltirone of 60 National Cancer Institute cell lines were associated with the microarray-based expression of 9,706 genes. By COMPARE and hierarchical cluster analyses, candidate genes were identified, which significantly predicted sensitivity or resistance of cell lines to miltirone.
