最新研究發(fā)現(xiàn),，孕婦患上乳癌后,，所面對的死亡和癌癥復發(fā)危險，并不比其他年輕乳癌病人來得大,。
早先的小型調查認為,，懷孕會使乳癌患者的病情惡化，但是這次最大規(guī)模調查的結論與之相反,。
美國得克薩斯大學安德森癌癥中心的彼得爾說：“只要發(fā)現(xiàn)早,，就能取得兼顧大人和孩子的治療結果。”
一般來說,，懷孕婦女尤其害怕患上乳癌,，因為既要治療母親又要避免傷害到胎兒。有些醫(yī)生則建議孕婦流產(chǎn),，以便集中精力治療母親,。
彼得爾研究小組在《癌癥》雜志發(fā)表最新調研報告,，該小組分析了1973年至2006年期間在安德森癌癥中心治療乳腺癌的652名患者的資料。
這些病人年齡都在35歲或者以下,，包括了104個懷了身孕的婦女,。其中51人懷孕期間確診為乳癌，另外53人在一年后患上這種病,。研究人員調查了她們患癌后連續(xù)10年的隨訪資料,，發(fā)現(xiàn)在癌癥復發(fā)、擴散和存活率方面,，上述病人跟其他乳癌患者基本相同,。調查還發(fā)現(xiàn)，孕婦的乳癌通常發(fā)現(xiàn)時已屬晚期,，這可能是因為病人和醫(yī)生都忽略了乳房的變化,。
乳癌對年輕女性侵害較大，她們的存活率也明顯要低,。醫(yī)學人員認為年齡可能是病變因素,，但目前還不清楚懷孕是不是原因之一。彼得爾說,，在最新調查中,，沒有發(fā)現(xiàn)懷孕婦女腫瘤生長比較快的證據(jù)。（生物谷Bioon.com）
生物谷推薦原始出處：
Cancer,，DOI：10.1002/cncr.24165,，Beth M. Beadle，George H. Perkins
The impact of pregnancy on breast cancer outcomes in women 35 years
Beth M. Beadle, MD, PhD 1, Wendy A. Woodward, MD, PhD 1, Lavinia P. Middleton, MD 2, Welela Tereffe, MD 1, Eric A. Strom, MD 1, Jennifer K. Litton, MD 3, Funda Meric-Bernstam, MD 4, Richard L. Theriault, DO 3, Thomas A. Buchholz, MD 1, George H. Perkins, MD 1 *
1Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
2Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
3Department of Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
4Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
BACKGROUND:
Some evidence suggests that women with pregnancy-associated breast cancers (PABC) have a worse outcome compared with historical controls. However, young age is a worse prognostic factor independently, and women with PABC tend to be young. The purpose of the current study was to compare locoregional recurrence (LRR), distant metastases (DM), and overall survival (OS) in young patients with PABC and non-PABC.
METHODS:
Data for 668 breast cancers in 652 patients aged 35 years were retrospectively reviewed. One hundred four breast cancers (15.6%) were pregnancy-associated; 51 cancers developed during pregnancy and 53 within 1 year after pregnancy.
RESULTS:
The median follow-up for all living patients was 114 months. Patients who developed PABC had more advanced T classification, N classification, and stage group (all P < .04) compared with patients with non-PABC. Patients with PABC had no statistically significant differences in 10-year rates of LRR (23.4% vs 19.2%; P = .47), DM (45.1% vs 38.9%; P = .40), or OS (64.6% vs 64.8%; P = .60) compared with patients with non-PABC. For those patients who developed breast cancer during pregnancy, any treatment intervention during pregnancy provided a trend toward improved OS compared with delaying evaluation and treatment until after delivery (78.7% vs 44.7%; P = .068).
CONCLUSIONS:
Young patients with PABC had no statistically significant differences in LRR, DM, or OS compared with those with non-PABC; however, pregnancy contributed to a delay in breast cancer diagnosis, evaluation, and treatment. Primary care and reproductive physicians should be aggressive in the workup of breast symptoms in the pregnant population to expedite diagnosis and allow multidisciplinary treatment. Cancer 2009. ? 2009 American Cancer Society.
