美國(guó)路易斯安那州立大學(xué)研究人員6月19日公布研究報(bào)告說,，綠茶中所含的多酚類活性成分EGCG或許可以減緩前列腺癌的生長(zhǎng),。
研究人員在美國(guó)新一期《癌癥預(yù)防研究》（Cancer Prevention Research）雜志上報(bào)告說，他們對(duì)26名年齡在41歲至72歲之間的前列腺癌患者進(jìn)行了測(cè)試,。
這些患者每天服用4粒富含EGCG的膠囊,，并在進(jìn)行前列腺切除手術(shù)的當(dāng)天停止用藥。他們的服藥期從12天至73天不等,，平均為34．5天,。
研究人員發(fā)現(xiàn)，這些患者血清中用來衡量前列腺癌生長(zhǎng)的3種標(biāo)記物的水平都有所下降，其中肝細(xì)胞生長(zhǎng)因子水平平均下降18．9％,，血管內(nèi)皮生長(zhǎng)因子水平下降9．9％，前列腺特異抗原水平平均下降10．4％,。一些患者血清內(nèi)的肝細(xì)胞生長(zhǎng)因子和血管內(nèi)皮生長(zhǎng)因子水平甚至下降了30％以上,。這些患者基本沒有出現(xiàn)不良反應(yīng)，肝功能也都正常,。
領(lǐng)導(dǎo)這項(xiàng)研究的路易斯安那州立大學(xué)保健學(xué)中心教授詹姆斯·卡德利表示,，綠茶中的活性成分能限制癌細(xì)胞快速生長(zhǎng)，但不一定能將腫瘤縮小,。不過,，綠茶確實(shí)可以作為化療和放療的有益補(bǔ)充?？ǖ吕€表示,，他們的研究只是小型測(cè)試，相關(guān)成果還需要大型研究加以確認(rèn),。
美國(guó)癌癥協(xié)會(huì)提供的數(shù)據(jù)顯示,，前列腺癌目前是美國(guó)男性的第二大癌癥死因。該協(xié)會(huì)預(yù)計(jì),，2009年,，美國(guó)死于前列腺癌的男性將達(dá)到2．7萬(wàn)人，新增病例將達(dá)到19．2萬(wàn)例,。（生物谷Bioon.com）
生物谷推薦原始出處：
Cancer Prevention Research 2, 531, June 1, 2009. doi: 10.1158/1940-6207.CAPR-08-0185
Lung Cancer Inhibitory Effect of Epigallocatechin-3-Gallate Is Dependent on Its Presence in a Complex Mixture (Polyphenon E)
Huijing Fu1, Jun He2, Fan Mei1, Qi Zhang2, Yukihiko Hara3, Seto Ryota2, Ronald A. Lubet4, Ruth Chen1, Da-Ren Chen1 and Ming You2,3
Authors' Affiliations: 1 Department of Energy, Environmental and Chemical Engineering, Washington University of St. Louis and 2 Department of Surgery, Campus Box, The Alvin J Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri; 3 Mitsui Norin Co., Ltd., Shizuoka, Japan; and 4 Chemoprevention Agent Development Research Group, National Cancer Institute, Bethesda, Maryland
Green tea has been shown to exhibit cancer-preventive activities in preclinical studies. However, (–)-epigallocatechin-3-gallate (EGCG) alone was shown to be ineffective in preventing lung tumorigenesis in mice by aerosol administration. In this study, Polyphenon E and Polyphenon E without EGCG were administered by aerosol delivery to A/J mice 2 weeks after carcinogen treatment and continuing daily throughout the remainder of the study (20 weeks). An improved aerosol delivery system with a custom-built atomizer, an efficient solvent remove system, and a nose-only exposure chamber was used to provide aerosols with stable size distribution. There were no significant differences in the size distributions of Polyphenon E and Polyphenon E without EGCG. With a relatively low dose level (4.19 mg/kg), Polyphenon E decreased tumor multiplicity by 53%, whereas Polyphenon E without EGCG at the same dose failed to inhibit lung carcinogenesis. These results indicate that aerosol administration can be an effective approach in chemoprevention study, and aerosolized Polyphenon E can significantly inhibit pulmonary adenoma formation and growth in A/J mice. Furthermore, in aerosolized form, EGCG, which is thought to be the most active component of Polyphenon E, has to be present with other tea catechins to show chemopreventive activity on lung tumorigenesis.
