用一種特別的激光掃描方法,，科學(xué)家們觀察到了大腦中癌細(xì)胞轉(zhuǎn)移建立的過程，新成果發(fā)表在12月在線出版的《自然—醫(yī)學(xué)》期刊上,。
腦癌患者通常會(huì)發(fā)生致命性的癌細(xì)胞轉(zhuǎn)移,。用一種名為多光子激光掃描顯微鏡的技術(shù)，F(xiàn)rank Winkler和同事實(shí)時(shí)觀察到了轉(zhuǎn)移過程形成的每個(gè)步驟,。他們還能在幾分鐘到幾個(gè)月的時(shí)間里,，跟蹤小鼠大腦深處血管中單個(gè)轉(zhuǎn)移癌細(xì)胞的命運(yùn)。
科學(xué)家們已經(jīng)確立出一整套的關(guān)鍵性步驟：在血管分枝處捕捉癌細(xì)胞,、退出血管,、持續(xù)聯(lián)結(jié)細(xì)胞和毛細(xì)胞，最后,，在血管周圍轉(zhuǎn)移癌細(xì)胞,。在活體中觀察到大腦癌細(xì)胞轉(zhuǎn)移形成的過程，將有助于科學(xué)家們深入了解癌細(xì)胞的發(fā)展過程,，并確立出相應(yīng)的治療方法,。（生物谷Bioon.com）
癌癥轉(zhuǎn)移相關(guān)研究：
Science：癌癥轉(zhuǎn)移可能比預(yù)想的早
Nature：與乳腺癌腫瘤形成和轉(zhuǎn)移有關(guān)的兩種miRNA
Cell：特殊細(xì)胞因子促使乳腺腫瘤轉(zhuǎn)移
Cell Stem Cell：癌癥干細(xì)胞控制腫瘤轉(zhuǎn)移假說被證實(shí)
Nature Reviews Cancer：科學(xué)家提出癌癥轉(zhuǎn)移新解釋
PNAS：非編碼RNA可控制癌癥轉(zhuǎn)移
Cell：腫瘤細(xì)胞具有“自激注入”能力
生物谷推薦原始出處：
Nature Medicine 20 December 2009 | doi:10.1038/nm.2072
Real-time imaging reveals the single steps of brain metastasis formation
Yvonne Kienast1,2, Louisa von Baumgarten1, Martin Fuhrmann2, Wolfgang E F Klinkert4, Roland Goldbrunner3, Jochen Herms2,5 & Frank Winkler1,5
Brain metastasis frequently occurs in individuals with cancer and is often fatal. We used multiphoton laser scanning microscopy to image the single steps of metastasis formation in real time. Thus, it was possible to track the fate of individual metastasizing cancer cells in vivo in relation to blood vessels deep in the mouse brain over minutes to months. The essential steps in this model were arrest at vascular branch points, early extravasation, persistent close contacts to microvessels and perivascular growth by vessel cooption (melanoma) or early angiogenesis (lung cancer). Inefficient steps differed between the tumor types. Long-term dormancy was only observed for single perivascular cancer cells, some of which moved continuously. Vascular endothelial growth factor-A (VEGF-A) inhibition induced long-term dormancy of lung cancer micrometastases by preventing angiogenic growth to macrometastases. The ability to image the establishment of brain metastases in vivo provides new insights into their evolution and response to therapies.
1 Department of Neurology, Ludwig-Maximilians University, Munich, Germany.
2 Department of Neuropathology, Ludwig-Maximilians University, Munich, Germany.
3 Department of Neurosurgery, Ludwig-Maximilians University, Munich, Germany.
4 Max Planck Institute of Neurobiology, Martinsried, Germany.
5 These authors contributed equally to this work.
