據一篇發(fā)表于FASEB Journal三月版的研究報告,，瑞典科學家發(fā)現,，深海魚中所富含的ω-3脂肪酸和二十二碳六烯酸(docosahexaenoic acid,DHA)及其衍生物在機體中能夠殺死神經母細胞瘤癌細胞,。這項發(fā)現或許為多種癌癥——如神經母細胞瘤、髓母細胞瘤、結腸癌、乳腺癌和前列腺癌等提供新的治療方法,。
在該研究中，科學家使DHA從神經系統中轉移到髓母細胞瘤中,，當DHA在細胞內代謝后,，再對細胞中的副產物進行分析。隨后科學家研究了DHA及其衍生物對癌細胞生長的影響,。研究結果表明,，DHA殺死了所有的癌細胞，而且由DHA衍生物產生的毒性比DHA本身更能有效地殺死癌細胞,。這表明,，DHA或可成為一種新的治療神經母細胞瘤或其他癌癥的新藥物。
FASEB雜志主編Gerald Weissmann稱,，這項研究對治療癌癥有重要意義,，由于DHA在保護人體健康上的重要作用，未來可根據DHA及其衍生物研制一類新的抗癌藥物,。（生物谷Bioon.com）
相關研究：
JAMA：DHA有助于早產女嬰神經系統發(fā)育
CMAJ：魚油對人的作用因人而異
JAMA：歐米茄-3脂肪酸對端粒有保護作用
生物谷推薦原始出處：
The FASEB Journal. 2010;24:906-915. doi: 10.1096/fj.09-137919.
Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates
Helena Gleissman*,1, Rong Yang, Kimberly Martinod, Magnus Lindskog*, Charles N. Serhan, John Inge Johnsen* and Per Kogner*
* Childhood Cancer Research Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden; and
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
1 Correspondence: Childhood Cancer Research Unit, Q6:05, Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children’s Hospital, S-171 76 Stockholm, Sweden.
Docosahexaenoic acid (DHA) protects neural cells from stress-induced apoptosis. On the contrary, DHA exerts anticancer effects, and we have shown that DHA induces apoptosis in neuroblastoma, an embryonal tumor of the sympathetic nervous system. We now investigate the DHA metabolome in neuroblastoma using a targeted lipidomic approach in order to elucidate the mechanisms behind the DHA-induced cytotoxicity. LC-MS/MS analysis was used to identify DHA-derived lipid mediators in neuroblastoma cells. Presence of the 15-lipoxygenase enzyme was investigated using immunoblotting, and cytotoxic potency of DHA and DHA-derived compounds was compared using the MTT cell viability assay. Neuroblastoma cells metabolized DHA to 17-hydroxydocosahexaenoic acid (17-HDHA) via 17-hydroperoxydocosahexaenoic acid (17-HpDHA) through 15-lipoxygenase and autoxidation. In contrast to normal neural cells, neuroblastoma cells did not produce the anti-inflammatory and protective lipid mediators, resolvins and protectins. 17-HpDHA had significant cytotoxic potency, with an IC50 of 3–6 μM at 72 h, compared to 12–15 μM for DHA. α-Tocopherol protected cells from 17-HpDHA-induced cytotoxicity. DHA inhibited secretion of prostaglandin-E2 and augmented the cytotoxic potency of the cyclooxygenase-2-inhibitor celecoxib. The cytotoxic effect of DHA in neuroblastoma is mediated through production of hydroperoxy fatty acids that accumulate to toxic intracellular levels with restricted production of its products, resolvins and protectins.—Gleissman, H., Yang, R., Martinod, K., Lindskog, M., Serhan, C. N., Johnsen, J. I., Kogner, P. Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates.
