瑞典斯德哥爾摩卡羅林斯卡醫(yī)學(xué)院的研究發(fā)現(xiàn),，消瘦的女孩日后更有可能患上乳癌,。與小時候較胖的女孩相比,，7歲時身材較瘦的女孩長大后患乳癌的風(fēng)險更大?？茖W(xué)家還發(fā)現(xiàn),，小時候稍胖的女孩患難以攻克的腫瘤的概率較小。
該研究報告發(fā)表在《乳癌研究》（Breast Cancer Research）雜志上,，研究為把童年時舊照片作為評估女性乳癌風(fēng)險的方法鋪平了道路,。瑞典科學(xué)家對6000名女性進(jìn)行了研究，其中半數(shù)女性為乳癌患者,，科學(xué)家依據(jù)她們7歲時體型“消瘦”,、“中等”或“較胖”分為三組。判斷基礎(chǔ)為這些女性的舊照片和她們的記憶,。研究人員驚訝地發(fā)現(xiàn),，小時候較胖的女性絕經(jīng)期患乳癌的風(fēng)險較小。之前的研究顯示,，肥胖的女性更易患乳癌,，而且她們死于乳癌的風(fēng)險高達(dá)50%。
科學(xué)家不確定瘦女孩易患乳癌的原因是什么,。他們表示,，新發(fā)現(xiàn)可能對判斷女性乳癌風(fēng)險具有重要意義。負(fù)責(zé)這項研究的李景梅(音譯)說：“小時候較胖的女孩患乳癌的風(fēng)險較低,，這似乎違反直覺,，因?yàn)樾律鷥后w重較重和成年人體質(zhì)指數(shù)較高已顯示會增加乳癌風(fēng)險,。促成這種保護(hù)效果的機(jī)制仍是未知數(shù)。鑒于存在的這些聯(lián)系和舊照片中兒童體型透露的信息,，兒童的胖瘦對構(gòu)建乳癌風(fēng)險或者預(yù)后模式有著潛在的用途,。”（生物谷Bioon.com）
更多閱讀：
Breast Cancer：維生素D和鈣能夠降低女性乳腺癌風(fēng)險
Cancer Research：發(fā)現(xiàn)乳腺癌致病基因
Nature：乳腺癌中的染色體重排情況
Cancer Research：microRNA-155促進(jìn)腫瘤發(fā)生或?yàn)槁?lián)系炎癥和癌癥橋梁 ...
生物谷推薦原文出處：
Breast Cancer Research 2010, 12:R23 | doi:10.1186/bcr2564
Effects of childhood body size on breast cancer tumour characteristics
Jingmei Li , Keith Humphreys , Louise Eriksson , Kamila Czene , Jianjun Liu and Per Hall
Introduction
Although a role of childhood body size in postmenopausal breast cancer risk has been established, less is known about its influence on tumour characteristics.
Methods
We studied the relationships between childhood body size and tumour characteristics in a Swedish population-based case-control study consisting of 2,818 breast cancer cases and 3,111 controls. Our classification of childhood body size was derived from a nine-level somatotype. Relative risks were estimated by odds ratios with 95% confidence intervals, derived from fitting unconditional logistic regression models. Association between somatotype at age 7 and tumour characteristics were evaluated in a case-only analysis where P-values for heterogeneity were obtained by performing one degree of freedom trend tests.
Results
A large somatotype at age 7 was found to be associated with decreased postmenopausal breast cancer risk. Although strongly associated with other risk factors such as age of menarche, adult body mass index and mammographic density, somatotype at age 7 remained a significant protective factor (odds ratio (OR) comparing large to lean somatotype at age 7 = 0.73, 95% confidence interval (CI) = 0.58-0.91, P trend = 0.004) after adjustment. The significant protective effect was observed within all subgroups defined by estrogen receptor (ER) and progesterone receptor (PR) status, with a stronger effect for ER-negative (0.40, 95% CI = 0.21-0.75, P trend = 0.002), than for ER-positive (0.80, 95% CI = 0.62-1.05, P trend = 0.062), tumours (P heterogeneity = 0.046). Somatotype at age 7 was not associated with tumour size, histology, grade or the presence or absence of metastatic nodes.
Conclusions
Greater body size at age 7 is associated with a decreased risk of postmenopausal breast cancer, and the associated protective effect is stronger for the ER-negative breast cancer subtype than for the ER-positive subtype.
