癌癥干細(xì)胞假說提出,，在一個(gè)腫瘤中，只有小部分的細(xì)胞能夠啟動(dòng)腫瘤的生長(zhǎng),。這一假說激發(fā)了尋找產(chǎn)生人類常見上皮性腫瘤的細(xì)胞的興趣,。 就前列腺癌這種情況而言，研究人員認(rèn)為,，管腔細(xì)胞是該種癌癥的細(xì)胞起源。但有關(guān)這一理論的證據(jù)主要是根據(jù)人類腫瘤的組織學(xué)研究或是對(duì)來自小鼠組織的腫瘤的研究,。
Andrew Goldstein及其同事使用了一種新的功能性檢驗(yàn)方法：他們從人類的良性前列腺組織中分離出了基底細(xì)胞和管腔細(xì)胞,，并用腫瘤基因轉(zhuǎn)變它們，然后再將這些細(xì)胞移植到小鼠體內(nèi),。 他們的結(jié)果表明,，基底細(xì)胞而非管腔細(xì)胞產(chǎn)生了與在人體中所見的前列腺腫瘤非常接近的前列腺腫瘤；研究人員提醒道,，當(dāng)在確定人類癌癥的細(xì)胞起源時(shí)僅僅根據(jù)組織學(xué)的研究可能會(huì)產(chǎn)生誤導(dǎo),。（生物谷Bioon.com）
生物谷近期特別推薦會(huì)議：
2010細(xì)胞治療研究進(jìn)展與臨床前沿研討會(huì) www.Cell-therapies.net 2010年9月23日-25日天津召開
第一屆腫瘤基礎(chǔ)和轉(zhuǎn)化醫(yī)學(xué)國(guó)際研討會(huì) www.cancerasia.org 2010年10月12日-10月15日上海召開
生物谷推薦原文出處：
Science DOI: 10.1126/science.1189992
Identification of a Cell of Origin for Human Prostate Cancer
Andrew S. Goldstein,1 Jiaoti Huang,2,3,6 Changyong Guo,2,4 Isla P. Garraway,2,4 Owen N. Witte1,5,6,*
Luminal cells are believed to be the cells of origin for human prostate cancer, because the disease is characterized by luminal cell expansion and the absence of basal cells. Yet functional studies addressing the origin of human prostate cancer have not previously been reported because of a lack of relevant in vivo human models. Here we show that basal cells from primary benign human prostate tissue can initiate prostate cancer in immunodeficient mice. The cooperative effects of AKT, ERG, and androgen receptor in basal cells recapitulated the histological and molecular features of human prostate cancer, with loss of basal cells and expansion of luminal cells expressing prostate-specific antigen and alpha-methylacyl-CoA racemase. Our results demonstrate that histological characterization of cancers does not necessarily correlate with the cellular origins of the disease.
1 Molecular Biology Institute, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
2 Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA.
3 Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA 90095, USA.
4 Department of Urology, UCLA, Los Angeles, CA 90095, USA.
5 Department of Microbiology, Immunology and Molecular Genetics; Department of Molecular and Medical Pharmacology; Howard Hughes Medical Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.
6 Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA 90095, USA.
