巴西和加拿大研究人員的一項最新研究表明,，癌癥患者感染H1N1可導(dǎo)致呼吸道窘迫綜合征（ARDS）和死亡等嚴(yán)重后果,。目前尚需進(jìn)一步研究數(shù)據(jù)以確定這些患者不良進(jìn)展的預(yù)測因素,。相關(guān)論文近期發(fā)表于《腫瘤學(xué)年鑒》（Ann Oncol）,。
該研究回顧了因新型H1N1感染導(dǎo)致記性呼吸衰竭的患者,，采用實時逆轉(zhuǎn)錄聚合酶鏈反映（RT-PCR）和尸檢對患者肺組織進(jìn)行病毒學(xué)和細(xì)胞學(xué)分析,。
研究共分析了8例年齡為55～65歲的患者,，其中5例為實體瘤（62.5%）,，3例為惡性血液腫瘤（37.5%）。研究發(fā)現(xiàn),，5例患者需接受機(jī)械通氣且最終死亡,，4例患者患上細(xì)菌性支氣管肺炎，所有死亡病例死亡原因為多器官衰竭,，3例存活患者肺部疾病較輕,。研究對所有患者進(jìn)行了肺組織檢查分析，并發(fā)現(xiàn)大部分患者出現(xiàn)彌漫性肺泡損傷,。研究還觀察到壞死性細(xì)支氣管炎和大面積出血,。（生物谷Bioon.com）
生物谷推薦原文出處：
Ann Oncol doi: 10.1093/annonc/mdq254
Severe novel influenza A (H1N1) infection in cancer patients
L. A. Hajjar1, T. Mauad2, F. R. B. G. Galas1, A. Kumar3, L. F. F. da Silva2, M. Dolhnikoff2, T. Trielli1, J. P. Almeida1, M. R. L. Borsato2, E. Abdalla4, L. Pierrot4, R. Kalil Filho1, J. O. C. Auler Jr1, P. H. N. Saldiva2 and P. M. Hoff5,*
Abstract
Background: The natural history and consequences of severe H1N1 influenza infection among cancer patients are not yet fully characterized. We describe eight cases of H1N1 infection in cancer patients admitted to the intensive care unit of a referral cancer center.
Patients and methods: Clinical data from all patients admitted with acute respiratory failure due to novel viral H1N1 infection were reviewed. Lung tissue was submitted for viral and bacteriological analyses by real-time RT-PCR, and autopsy was conducted on all patients who died.
Results: Eight patients were admitted, with ages ranging from 55 to 65 years old. There were five patients with solid organ tumors (62.5%) and three with hematological malignancies (37.5%). Five patients required mechanical ventilation and all died. Four patients had bacterial bronchopneumonia. All deaths occurred due to multiple organ failure. A milder form of lung disease was present in the three cases who survived. Lung tissue analysis was performed in all patients and showed diffuse alveolar damage in most patients. Other lung findings were necrotizing bronchiolitis or extensive hemorrhage.
Conclusions: H1N1 viral infection in patients with cancer can cause severe illness, resulting in acute respiratory distress syndrome and death. More data are needed to identify predictors of unfavorable evolution in these patients.
