一項(xiàng)研究發(fā)現(xiàn),，有針對(duì)性地打擊一小群被認(rèn)為促進(jìn)了黑色素瘤的腫瘤細(xì)胞有可能幫助治療這種可能致命的皮膚癌。黑色素瘤常常產(chǎn)生含有各種遺傳類型的腫瘤細(xì)胞的腫瘤,。為了檢驗(yàn)一個(gè)假說(shuō),，即這些腫瘤內(nèi)的一小群具有遺傳相似性的細(xì)胞促進(jìn)了黑色素瘤的生長(zhǎng)，Hinrich Abken及其同事使用了一種免疫療法瞄準(zhǔn)了被認(rèn)為是補(bǔ)充這種腫瘤的細(xì)胞,。這組作者向移植到小鼠的人類黑色素瘤注射了經(jīng)過(guò)改造的人類免疫細(xì)胞,，這些細(xì)胞被改造成了能夠殺死含有兩種癌癥相關(guān)蛋白的黑色素瘤細(xì)胞,。這組作者發(fā)現(xiàn),，即便這些癌癥相關(guān)蛋白只裝飾了典型的黑色素瘤病灶的不到2%的黑色素瘤細(xì)胞，以這兩種蛋白（而不是以其他蛋白）為靶標(biāo)的免疫細(xì)胞在很大程度上讓這些腫瘤縮小并且在注射后的多于36周的時(shí)間里遏制了黑色素瘤,。這組作者說(shuō),，這些免疫細(xì)胞很可能通過(guò)打開(kāi)了參與程序性細(xì)胞死亡的酶從而毀滅了它們的目標(biāo)細(xì)胞。
這組作者報(bào)告說(shuō),，盡管這些表面蛋白本身不太可能是這種腫瘤的關(guān)鍵分子成分,，這些蛋白標(biāo)記了一小群可能作為黑色素瘤核心的腫瘤細(xì)胞。這組作者提出,，研發(fā)治療黑色素瘤的藥物的工作可能因?yàn)槊闇?zhǔn)這一群腫瘤細(xì)胞而獲益,。（生物谷Bioon.com）
生物谷推薦英文摘要：
PNAS doi: 10.1073/pnas.1009069108
Eradication of melanomas by targeted elimination of a minor subset of tumor cells
Patrick Schmidta, Caroline Kopeckya, Andreas Hombacha, Paola Zigrinob, Cornelia Mauchb,c, and Hinrich Abkena,c,1
Proceeding on the assumption that all cancer cells have equal malignant capacities, current regimens in cancer therapy attempt to eradicate all malignant cells of a tumor lesion. Using in vivo targeting of tumor cell subsets, we demonstrate that selective elimination of a definite, minor tumor cell subpopulation is particularly effective in eradicating established melanoma lesions irrespective of the bulk of cancer cells. Tumor cell subsets were specifically eliminated in a tumor lesion by adoptive transfer of engineered cytotoxic T cells redirected in an antigen-restricted manner via a chimeric antigen receptor. Targeted elimination of less than 2% of the tumor cells that coexpress high molecular weight melanoma-associated antigen (HMW-MAA) (melanoma-associated chondroitin sulfate proteoglycan, MCSP) and CD20 lastingly eradicated melanoma lesions, whereas targeting of any random 10% tumor cell subset was not effective. Our data challenge the biological therapy and current drug development paradigms in the treatment of cancer.
<P><STRONG> 推薦會(huì)議：</STRONG></P>
<P><A title="" href="http://www.medsci.cn/z/rad-sci/Index.shtml" target=_blank><IMG border=0 src="http://www.bioon.com/biology/UploadFiles/201102/2011022317123138.jpg" width=500 height=84></A></P>
<A title="" href="http://www.medsci.cn/z/rad-sci/Index.shtml" target=_blank style="text-decoration:none"><FONT color=#000000><P>第一屆國(guó)際醫(yī)學(xué)影像和放射學(xué)新進(jìn)展暨學(xué)術(shù)論著發(fā)表策略研討會(huì) <BR>2011 Medical Imaging and Radiological Innovations Conference</P>
<P>會(huì)議時(shí)間：2011年3月25日--3月27日</P>
<P>會(huì)議地點(diǎn)：上海醫(yī)學(xué)院路復(fù)旦醫(yī)學(xué)院明道樓</P></FONT></A>
