美國(guó)8日公布的一項(xiàng)最新研究顯示，睡眠不足會(huì)提高患結(jié)腸腺瘤甚至結(jié)腸癌的風(fēng)險(xiǎn),。據(jù)稱(chēng),，這是研究人員首次發(fā)現(xiàn)睡眠不足與結(jié)腸腺瘤存在關(guān)聯(lián)。
這項(xiàng)研究是由美國(guó)凱斯西儲(chǔ)大學(xué)醫(yī)學(xué)院等機(jī)構(gòu)的研究人員完成的,。研究涉及1240名病人,，其中338人被診斷患有結(jié)腸腺瘤，而在這些患者中,，大多數(shù)表示他們每天的睡眠時(shí)間不足6小時(shí),。
調(diào)查通過(guò)問(wèn)詢(xún)方式進(jìn)行，所涉及的問(wèn)題包括被調(diào)查對(duì)象在過(guò)去1個(gè)月的睡眠情況,、是否經(jīng)常有睡眠問(wèn)題,、每晚睡眠多長(zhǎng)時(shí)間等。結(jié)果發(fā)現(xiàn),，每天平均睡眠不足6小時(shí)的人要比每天睡眠7小時(shí)以上的人更容易患結(jié)腸腺瘤,，前者患此病的幾率比后者高50％。結(jié)腸腺瘤有些是良性腫瘤,，但有些也會(huì)轉(zhuǎn)為惡性腫瘤,。
相關(guān)研究成果刊登在新一期美國(guó)《癌癥》雜志上。（生物谷Bioon.com）
生物谷推薦原文出處：
Cancer, 2011; 117 (4): 841 DOI: 10.1002/cncr.25507
Short duration of sleep increases risk of colorectal adenoma
Cheryl L. Thompson PhD1,2,3,4, Emma K. Larkin PhD2,3,5, Sanjay Patel MD3,4,5,6, Nathan A. Berger MD3,4,6, Susan Redline MD2,3,4,5, Li Li MD, PhD1,2,3,4,*
Keywords:sleep duration;quality of sleep;colorectal adenoma;Pittsburgh Sleep Quality Index
Abstract
BACKGROUND:
Short duration and poor quality of sleep have been associated with increased risks of obesity, cardiovascular disease, diabetes mellitus, and total mortality. However, few studies have investigated their associations with risk of colorectal neoplasia.
METHODS:
In a screening colonoscopy-based case-control study, the Pittsburg Sleep Quality Index (PSQI) was administered to 1240 study participants before colonoscopy.
RESULTS:
Three hundred thirty-eight (27.3%) of the participants were diagnosed with incident colorectal adenomas. Although there was no appreciable difference in the overall PSQI score between cases and adenoma-free controls (5.32 vs 5.11; P = .37), the authors found a statistically significant association of colorectal adenoma with the PSQI component 3, which corresponds to sleep duration (P = .02). Cases were more likely to average less than 6 hours of sleep per night (28.9% vs 22.1% in controls, P = .01). In multivariate regression analysis adjusted for age, gender, race, smoking, family history of colorectal cancer, and waist-to-hip ratio, individuals averaging less than 6 hours per night had an almost 50% increase in risk of colorectal adenomas (OR = 1.47; CI = 1.05-2.06, P for trend = .02) as compared with individuals sleeping at least 7 hours per night. Cases were also more likely to report being diagnosed with sleep apnea (9.8% vs 6.5%, P = .05) and more likely to have worked alternate shifts (54.0% vs 46.1%, P = .01), although these differences were not significant in multivariate models.
CONCLUSIONS:
Shorter duration of sleep significantly increases risk of colorectal adenomas. The authors' results suggest sleep duration as a novel risk factor for colorectal neoplasia.
