20歲開始禿頂?shù)哪惺拷窈蠡记傲邢侔┑娘L(fēng)險可能更高,。這也許意味著年輕時禿頂?shù)哪行钥梢越邮芮傲邢侔┖Y查，從而盡早發(fā)現(xiàn)這一疾病,。研究報告由2月15日出版的最新一期法國Annals of Oncology發(fā)表,。
巴黎笛卡爾大學(xué)教授菲利普·吉羅自2004年9月起帶領(lǐng)同事進行這一研究。他們的研究對象為388名正在接受前列腺癌治療男性與281名健康男性,。
研究人員先讓所有人填寫調(diào)查問卷,，回答有關(guān)患前列腺癌問題，然后讓他們從四張不同程度禿頂照片中選擇最能代表自己20,、30及40歲頭發(fā)狀況的照片,。這四張照片上的發(fā)型分別是正常,、前額脫發(fā)、頭頂脫發(fā)以及前額頭頂均脫發(fā),。
研究人員還訪問受訪前列腺癌患者的醫(yī)生,，讓他們提供患者相關(guān)資料，如病人患病類型,、患病年齡,、患病階段以及治療方法。
研究共進行28個月,。這些前列腺癌患者的年齡為46至84歲,。
研究人員對比后發(fā)現(xiàn),，患前列腺癌男性中,，37人在20多歲時開始出現(xiàn)不同程度脫發(fā)，健康組中脫發(fā)的只有14人,。
參與這一研究的加拿大蒙特利爾大學(xué)助理教授邁克爾·亞薩說,，所有參與調(diào)查的志愿者中，只有三個人20歲時處于禿頂?shù)牡谌A段,，即頭頂脫發(fā),，沒有人處于第四階段，即前額頭頂都脫發(fā),。但是統(tǒng)計數(shù)據(jù)顯示,，只要20多歲開始禿頂，無論處于哪一階段,，今后患前列腺癌的風(fēng)險都會翻倍,。
不過，那些30或40多歲才開始禿頂?shù)哪行曰记傲邢侔┑娘L(fēng)險與健康組相比并無差別,。另外,，開始禿頂時年齡小并不意味著患前列腺癌會更早。
亞薩說,，研究人員應(yīng)該進一步研究,，擴大調(diào)查范圍，增加深度,，從而確定雄性激素,、早禿與前列腺癌的關(guān)系。（生物谷Bioon.com）
生物谷推薦原文出處：
Ann Oncol (2011) doi: 10.1093/annonc/mdq695
Male pattern baldness and the risk of prostate cancer
M. Yassa1, M. Saliou1, Y. De Rycke2, C. Hemery3, M. Henni1, J. M. Bachaud4, N. Thiounn5, J. M. Cosset3 and P. Giraud3,6,*
Abstract
Background: Androgens play a role in the development of both androgenic alopecia, commonly known as male pattern baldness, and prostate cancer. We set out to study if early-onset androgenic alopecia was associated with an increased risk of prostate cancer later in life.
Patients and methods: A total of 669 subjects (388 with a history of prostate cancer and 281 without) were enrolled in this study. All subjects were asked to score their balding pattern at ages 20, 30 and 40. Statistical comparison was subsequently done between both groups of patients.
Results: Our study revealed that patients with prostate cancer were twice as likely to have androgenic alopecia at age 20 [odds ratio (OR) 2.01, P?=?0.0285]. The pattern of hair loss was not a predictive factor for the development of cancer. There was no association between early-onset alopecia and an earlier diagnosis of prostate cancer or with the development of more aggressive tumors.
Conclusions: This study shows an association between early-onset androgenic alopecia and the development of prostate cancer. Whether this population can benefit from routine prostate cancer screening or systematic use of 5-alpha reductase inhibitors as primary prevention remains to be determined.
