一項(xiàng)針對(duì)新加坡華族的研究顯示,，過(guò)瘦人群與過(guò)胖人群一樣,，患結(jié)腸癌的風(fēng)險(xiǎn)均比較高,。
據(jù)新加坡《海峽時(shí)報(bào)》3日?qǐng)?bào)道,，這項(xiàng)研究由新加坡國(guó)立大學(xué)和美國(guó)明尼蘇達(dá)大學(xué)研究人員合作完成,，研究對(duì)象是5萬(wàn)多名新加坡華族人,，論文將刊登在美國(guó)《癌癥》雜志6月號(hào)上。
研究人員根據(jù)身高體重指數(shù)（BMI）區(qū)分研究對(duì)象,。他們發(fā)現(xiàn),，身高體重指數(shù)低于18．5的過(guò)瘦人群，罹患結(jié)腸癌的風(fēng)險(xiǎn)比身高體重指數(shù)在21．5至24．4之間的“理想體重”人群高33％,，而身高體重指數(shù)高于27．4的過(guò)胖人群則比“理想體重”群體高46％,。
身高體重指數(shù)是衡量人體健康狀況的一個(gè)參考指數(shù)，其計(jì)算方法為體重（公斤）除以身高（米）的平方,。
參與這項(xiàng)研究的新加坡國(guó)立大學(xué)研究人員說(shuō),，他們對(duì)這一發(fā)現(xiàn)感到意外，仍在尋求生物學(xué)角度的合理解釋,。
研究人員在其論文中提出的一項(xiàng)解釋是,，過(guò)瘦人群罹患結(jié)腸癌的風(fēng)險(xiǎn)較高，可能與一種叫做“DNA氧化應(yīng)激損傷”的輕微炎癥有關(guān),，這種炎癥破壞患者的免疫系統(tǒng),，讓癌細(xì)胞得以增殖。
至于過(guò)胖人群易患結(jié)腸癌,，一般認(rèn)為是因?yàn)檫^(guò)胖者體內(nèi)的胰島素較多,，可能削弱了阻止腫瘤生長(zhǎng)的機(jī)體免疫力。（生物谷Bioon.com）
生物谷推薦原文出處：
Cancer DOI: 10.1002/cncr.25936
Body mass index and risk of colorectal cancer in chinese singaporeans?
Andrew O. Odegaard PhD, MPH1,*, Woon Puay Koh PhD2, Mimi C. Yu PhD3, Jian Min Yuan PhD, MD1,3Article first published online: 24 FEB 2011
Keywords:body mass index;obesity;underweight;Asians;colorectal cancer
Abstract
BACKGROUND:
The authors chose to examine the association between body mass index (BMI) and incident colorectal cancer across the spectrum of BMI, including underweight persons, because detailed prospective cohort data on this topic in Asians is scarce, as is data on underweight persons (BMI, <18.5 kg/m2) in any population.
METHODS:
Analysis of the Singapore Chinese Health Study included 51,251 men and women aged 45-74 years enrolled in 1993-1998 and followed through 2007. Incident cancer cases and deaths among cohort members were identified through record linkage, and 980 cases were identified. Cox regression models were used to investigate the association of baseline BMI with risk of incident colorectal cancer during a mean of 11.5 years of follow-up.
RESULTS:
A significant, U-shaped, quadratic association was observed between BMI and colon cancer risk, with increased risk in BMIs ≥27.5 and <18.5 kg/m2. The association was more pronounced in never smokers and most prominent when further limiting the sample to those free of diabetes and cases with longer than 5 years of follow-up. Localized cases had a more pronounced association in BMIs ≥27.5, whereas advanced cases had a more pronounced association in BMIs <18.5 kg/m2. No association was found in relation to rectal cancer risk. The association was also stronger among patients aged 65 years and older.
CONCLUSIONS:
BMI displays a U-shaped, quadratic association with colon cancer risk in this Chinese population in Southeast Asia. Cancer 2011;. ? 2011 American Cancer Society.
