美國研究人員8月15日報(bào)告說，動(dòng)物研究顯示,，人參提取物活性成分——人參炔三醇和類似化合物有助于緩解某些癌癥療法的副作用,。
位于紐約的斯隆－凱特林癌癥研究所的研究人員合成了類似于人參炔三醇的化合物,，然后在患有乳腺癌或結(jié)腸癌的實(shí)驗(yàn)鼠身上展開實(shí)驗(yàn),，測試這種化合物抵消化療或放療副作用的能力。結(jié)果顯示,，在接受放療前為實(shí)驗(yàn)鼠注射這種化合物,，可以減少放療引起的體重減少和血細(xì)胞損傷。
研究人員認(rèn)為,，人參炔三醇和類似化合物都能減少抗癌藥紫杉醇所致的外周神經(jīng)損傷和惡心引發(fā)的體重下降,，并能減少抗癌藥5-氟尿嘧啶對紅細(xì)胞和白細(xì)胞的損傷，從而減少服藥者感染和貧血的風(fēng)險(xiǎn),。
這項(xiàng)研究成果當(dāng)天發(fā)表在美國新一期《國家科學(xué)院院刊》上,。研究人員表示，人參炔三醇和類似化合物可以成為輔助癌癥治療的一種臨床選項(xiàng),。不過,，在進(jìn)行臨床測試前，需要對人參炔三醇類似化合物的化學(xué)結(jié)構(gòu)進(jìn)行優(yōu)化,。(生物谷 Bioon.com)
doi:10.1073/pnas.1111332108
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Multifaceted cytoprotection by synthetic polyacetylenes inspired by the ginseng-derived natural product, panaxytriol
Chou, Ting-Chao; Dong, Huajin; Zhang, Xiuguo; Lei, Xiaoguang; Hartung, John; Zhang, Yandong; Lee, Jun Hee; Wilson, Rebecca M.; Danishefsky, Samuel J.
We describe herein the discovery of a series of panaxytriol (PXT)-derived polyacetylene small molecules with promising cytoprotectiveactivity. In mouse xenograft models, we have demonstrated the capacity of our synthetic analogs to mitigate a range of cancertherapeutic agent-induced toxicities, including body weight loss, lethality, neurotoxicity, and hematotoxicity. Our PXT analogshave also been found to reduce radiation-induced body weight loss and lethality in mouse models. Moreover, several PXT analogsappear to exhibit moderate in vivo antiinflammatory activity as well as in vitro immunoenhancing capabilities. These compoundsappear to derive their activity through induction of cancer preventive phase 2 enzymes. The studies described herein suggestthat coadministration of a PXT-derived agent with cancer chemotherapeutics or radiation therapy may serve to mitigate a rangeof therapy-associated toxicities.
