肺腺癌是常見于非吸煙者的一種非小細胞肺癌形式，間皮瘤是能被石棉觸發(fā)的一種罕見癌癥,。紐約大學癌癥研究所研究人員正在從事于一種血液測試,，這種血液測試的目的是測定與這些癌癥形式相關(guān)的抗體，早期診斷疾病,，甚至點出高風險的人,。
肺腺癌和間皮瘤癌細胞在它們的表面有聚糖生物標志物，病人甚至是早期的也有這些聚糖的抗體,，研究人員已創(chuàng)造了用286個不同聚糖點提前制備的印刷聚糖芯片,。作為高能量平臺的一部分，這能被用于篩查血清樣本來鑒定生物標志物,。課題組正在比較來自患惡性間皮瘤病人的與接觸石棉但無疾病癥狀的高疾病風險人的血清,。
雖然這個測試是在非常早的階段，但它能幫助醫(yī)生提醒有發(fā)生這些癌癥風險的人,。這可能尤其對可能沒有被正式地篩查的非吸煙者有用,，對那些可能對治療反應不好需要更侵略性治療方法牟疾病晚期病人也一樣有用。這將允許為病人特定治療和更好結(jié)果的治療（與在醫(yī)療系統(tǒng)上更低負擔一樣）,，也能幫助鑒定藥物發(fā)展的新路線,。（生物谷bioon.com)
doi:10.1504/IJBRA.2011.043771
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Processing and analysis of serum antibody binding signals from Printed Glycan Arrays for diagnostic and prognostic applications
Marko I. Vuskovic, Hongyu Xu, Nicolai V. Bovin, Harvey I. Pass, Margaret E. Huflejt
Abstract Procedures for data preprocessing, quality control, data analysis, evaluation and visualization of the new high-throughput biomarker platform based on printed glycan arrays (PGA) are presented in this paper. PGAs are similar in concept to DNA arrays but contain deposits of various carbohydrate structures (glycans) instead of spotted DNAs. PGA biomarker discovery for the early detection, diagnosis and prognosis of human malignancies and viral diseases is based on the response of the immune system as measured by the level of binding of anti-glycan antibodies from human serum to the glycans on the array. Procedures related to PGA data processing are herein demonstrated in a pilot study of cases representing 50 sera from patients with malignant mesothelioma and a control sample of 65 sera from high risk subjects exposed to asbestos without symptoms of disease.
