2011年5月,，《英國(guó)醫(yī)學(xué)雜志》刊登歐洲多國(guó)進(jìn)行的一項(xiàng)大規(guī)模研究顯示，飲酒與癌癥之間存在非常明顯的關(guān)聯(lián),，男性癌癥病例中有十分之一都可以歸結(jié)到與飲酒有關(guān),，研究人員因此呼吁人們?yōu)榱松眢w健康應(yīng)該減少飲酒量,。
近日，Am J Clin Nutr雜志刊登的一項(xiàng)針對(duì)87000多名女性和47000多名男性的研究成果,。該研究的主要工作者旨在找到大腸癌與酒精之間的聯(lián)系,，如果兩者之間有聯(lián)系，研究人員想進(jìn)一步探討酒精攝入量以及飲酒家族史與大腸癌的之間的相關(guān)性,。在這項(xiàng)研究過(guò)程中,，自1980年來(lái)，共有1801例大腸癌患者通過(guò)隨訪被確診,。
研究結(jié)果表明：有飲酒家族史的人每日攝入酒精量多于30克將大大增加罹患大腸癌的風(fēng)險(xiǎn),。罹患大腸癌最大風(fēng)險(xiǎn)的做法是吃紅肉、大量吸煙,、極少攝入葉酸等,。而沒(méi)有飲酒家族史的受試者則未顯示出酒精攝入和罹患大腸癌之間的相關(guān)性。
但研究并沒(méi)有對(duì)飲酒形式包括規(guī)律飲酒或偶爾大量飲酒進(jìn)行相關(guān)評(píng)測(cè),，同時(shí)研究數(shù)據(jù)也不能表明罹患癌癥的風(fēng)險(xiǎn)隨飲酒量增加而提高,。研究數(shù)據(jù)也證明：飲酒家族史陽(yáng)性者在攝入足量的葉酸后，并不能降低罹患大腸癌的風(fēng)險(xiǎn),，相關(guān)人士認(rèn)為諸如健康飲食等其他生活習(xí)慣可能在大腸癌發(fā)病因素中也起重要作用。
總之,，這個(gè)研究再次支持了具有飲酒家族史的人大量飲酒會(huì)增加患癌幾率這一觀點(diǎn),。(生物谷 Bioon.com)
doi:10.3945/ajcn.111.022145
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PMID:
Alcohol consumption and the risk of colon cancer by family history of colorectal cancer
Eunyoung Cho,Jung Eun Lee,Eric B Rimm,Charles S Fuchs, andEdward L Giovannucci
Background: Individuals with a family history of colorectal cancer may be more susceptible to adverse effects of alcohol consumption.
Objective: We investigated whether the association between alcohol consumption and colon cancer risk differed by family history of colorectal cancer.
Design: We conducted prospective studies in women and men in the Nurses’ Health Study and Health Professionals Follow-Up Study, respectively. Alcohol consumption was first assessed in 1980 in women and in 1986 in men.
Results: During a follow-up of 26 y among 87,861 women and 20 y among 47,290 men, we documented 1801 cases of colon cancer (1094 women and 707 men). Higher alcohol consumption was associated with an elevated risk of colon cancer, although the association was significant only for the highest intake category of ≥30 g/d, with no significant linear trend. The association between alcohol consumption and colon cancer risk differed by family history of colorectal cancer; in comparison with nondrinkers, the pooled multivariate RRs for alcohol consumption of ≥30 g/d were 1.23 (95% CI: 0.96, 1.57; NS) among those with no family history and 2.02 (95% CI: 1.30, 3.13) among those with a family history of colorectal cancer (P value test for difference = 0.05). In comparison with nondrinkers with no family history, the RR for colon cancer was 2.80 (95% CI: 2.00, 3.91) for individuals who consumed ≥30 g/d and who had a family history of colorectal cancer.
Conclusion: Reducing alcohol consumption may decrease the incidence of colon cancer, especially among those with a family history of colorectal cancer.
