近日，一項(xiàng)刊登在Canadian Journal of Physiology and Pharmacology雜志上的研究表明：在我們?nèi)粘ｏ嬍辰Y(jié)構(gòu)中增加維生素和礦物質(zhì)成分能降低罹患結(jié)腸癌的風(fēng)險(xiǎn),。
研究人員將大鼠長時(shí)間暴露在致癌環(huán)境下誘發(fā)大鼠癌癥的發(fā)生,，同時(shí)科研人員在老鼠日常飲食中添加了多種維生素和礦物質(zhì),，結(jié)果發(fā)現(xiàn)大鼠患上結(jié)腸癌的風(fēng)險(xiǎn)低于對照組,。
在整個(gè)實(shí)驗(yàn)過程中,，研究人員在給予大鼠高脂肪食物飼養(yǎng)連續(xù)32個(gè)周期后，將大鼠隨機(jī)分成六組,。之后將六組老鼠都暴露在有致癌物質(zhì)存在的環(huán)境下,，誘發(fā)老鼠癌癥的發(fā)生,。
結(jié)果表明：用高脂肪、低纖維食物飼養(yǎng)的老鼠基本上都出現(xiàn)了癌前病變癥狀,，而同樣用這些食物喂養(yǎng)的老鼠在每天給予多種維生素和礦物質(zhì)情況下,，癌前病變的發(fā)生率降低了84%。而且在整個(gè)實(shí)驗(yàn)過程中,，這些得到維生素和礦物質(zhì)補(bǔ)充的老鼠體內(nèi)且沒有腫瘤的發(fā)生,。
研究人員表示：維生素和礦物質(zhì)成分或許能協(xié)同發(fā)揮抗癌效果，由此猜測可能通過合理補(bǔ)充維生素和礦物質(zhì)來降低罹患結(jié)腸癌的風(fēng)險(xiǎn),。(生物谷 Bioon.com)
doi:10.1139/y11-100
PMC:
PMID:
Multivitamin and mineral supplementation in 1,2-dimethylhydrazine induced experimental colon carcinogenesis and evaluation of free radical status, antioxidant potential, and incidence of ACF
Albert Baskar Arul,a Ignacimuthu Savarimuthu,b Mohammed A. Alsaif,a Khalid S. Al Numaira
This study was performed to determine the chemopreventive and antioxidant status of multivitamin and mineral (0.01% in drinking water, ad libitum) supplements in 1,2-dimethylhydrazine (DMH)-induced experimental colon carcinogenesis. Experimental colon carcinogenesis was induced in male albino Wistar rats by injecting DMH (20 mg·(kg body mass)–1) once weekly for 15 consecutive weeks, and administering a multivitamin supplement in 3 regimes (initiation, post-initiation, and entire experimental period) for 32 weeks. We studied lipid peroxidation products (thiobarbituric acid reactive substances, lipid hydroperoxides, conjugated dienes) in the circulation and in the tissues, antioxidant status (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and non-enzymatic antioxidant-reduced glutathione) of the tissues, aberrant crypt foci (ACF), and histopathological alterations. DMH-induced rats had an increase in lipid peroxidation products and a lower antioxidant status compared with control animals. Multivitamin and mineral supplementation during the initiation, post-initiation, and the entire study period significantly decreased the levels of lipid peroxidation products in circulation and colonic tissues, significantly elevated the activities of the antioxidant enzymes and reduced glutathione to near normalcy in DMH-induced rats. The incidence of ACF was reduced to 84.1% in rats supplemented with multivitamin and minerals for the entire study and prevented the colonic tissue from histopathological alterations induced by DMH.
