機體攝取適當?shù)臓I養(yǎng)素對腫瘤的預防是有幫助的,，但我們還不能完全明確不同群體攝取某些個別營養(yǎng)物質(zhì)對腫瘤預防的確切作用。近來,，Arch Intern Med雜志發(fā)表的一項研究表明：罹患心血管疾病的人服用B族維生素和Ω3不飽和脂肪酸并不能達到預防腫瘤的目的,。
研究人員共招募了2,501名受試者包括514名女性和1,987名男性，男性受試者占受試者總數(shù)的79.4%,，這些受試者年齡均在45至80歲之間,。受試者在參與研究之前的12個月內(nèi)都曾有缺血性中風、不穩(wěn)定心絞痛或者急性心肌梗塞等疾病,，工作人員參試者隨機分組,，并從2003年2月開始就隨訪研究，直至2009年7月結(jié)束,。
結(jié)果發(fā)現(xiàn)2.3%的受試者因罹患腫瘤而死亡,，7%的受試者包括145名男性和29名女性體內(nèi)出現(xiàn)的原發(fā)性腫瘤，男性受試者罹患腫瘤率為83.3%,，罹患腫瘤的死亡率為81%,。這些數(shù)據(jù)證實受試者補充B族維生素、Ω3不飽和脂肪酸與是否罹患腫瘤之間并沒有直接的聯(lián)系,。
不僅B族維生素和Ω3不飽和脂肪酸對腫瘤的預防沒有明顯效果,，研究還發(fā)現(xiàn)這兩種營養(yǎng)物質(zhì)甚至能增加女性罹患腫瘤的風險。研究人員表示由于參試人數(shù)較少,，這些數(shù)據(jù)只是通過初步試驗分析得到的,，結(jié)果的可靠性還有待于進一步證實。（生物谷Bioon.com）
doi:10.1001/archinternmed.2011.1450
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B Vitamin and/or -3 Fatty Acid Supplementation and Cancer
Valentina A. Andreeva, PhD; Mathilde Touvier, PhD; Emmanuelle Kesse-Guyot, PhD; Chantal Julia, MD; Pilar Galan, MD; Serge Hercberg, MD
Background To advance knowledge about the cancer-chemopreventive potential of individual nutrients, we investigated the effects of B vitamin and/or -3 fatty acid supplements on cancer outcomes among survivors of cardiovascular disease.
Methods This was an ancillary study of the Supplementation With Folate, Vitamins B6 and B12 and/or Omega-3 Fatty Acids (SU.FOL.OM3) secondary prevention trial (2003-2009). In all, 2501 individuals aged 45 to 80 years were randomized in a 2 x 2 factorial design to one of the following 4 daily supplementation groups: (1) 5-methyltetrahydrofolate (0.56 mg), pyridoxine hydrochloride (vitamin B6; 3 mg) and cyanocobalamin (vitamin B12; 0.02 mg); (2) eicosapentaenoic and docosahexaenoic acid (600 mg) in a 2:1 ratio; (3) B vitamins and -3 fatty acids; or (4) placebo. Overall and sex-specific hazard ratios (HRs) and 95% CIs regarding the cancer outcomes were estimated with Cox proportional hazards models.
Results After 5 years of supplementation, incident cancer was validated in 7.0% of the sample (145 events in men and 29 in women), and death from cancer occurred in 2.3% of the sample. There was no association between cancer outcomes and supplementation with B vitamins (HR, 1.15 [95% CI, 0.85-1.55]) and/or -3 fatty acids (HR, 1.17 [95% CI, 0.87-1.58]). There was a statistically significant interaction of treatment by sex, with no effect of treatment on cancer risk among men and increased cancer risk among women for -3 fatty acid supplementation (HR, 3.02 [95% CI, 1.33-6.89]).
Conclusion We found no beneficial effects of supplementation with relatively low doses of B vitamins and/or -3 fatty acids on cancer outcomes in individuals with prior cardiovascular disease.
