據(jù)美國(guó)癌癥研究協(xié)會(huì)《癌癥預(yù)防研究雜志》上發(fā)表的一項(xiàng)研究，姜根補(bǔ)充劑能降低結(jié)腸發(fā)生炎癥時(shí)的相關(guān)標(biāo)志物,，這表明姜根補(bǔ)充劑有可能用于預(yù)防結(jié)腸癌,。
美國(guó)密歇根大學(xué)醫(yī)學(xué)院的助理教授,、公共衛(wèi)生碩士Suzanna M. Zick和他的同事招募了30名患者，并隨機(jī)分成兩組,，一組給予安慰劑,，一組給予兩克姜根補(bǔ)充劑，兩組都給予28天,。
28天后,，研究人員測(cè)量了結(jié)腸發(fā)生炎癥反應(yīng)時(shí)的標(biāo)記物水平,，結(jié)果發(fā)現(xiàn)絕大多數(shù)生物標(biāo)記物都顯著降低，在其他一些標(biāo)記物中也呈現(xiàn)顯著下降趨勢(shì),。
Zick說(shuō)：“以往研究已經(jīng)證實(shí)炎癥是結(jié)腸癌發(fā)生的前兆,，但需要開展另一項(xiàng)試驗(yàn)研究探討姜根補(bǔ)充劑對(duì)結(jié)腸癌發(fā)生風(fēng)險(xiǎn)的影響”。
Zick說(shuō)：“我們應(yīng)用同樣的姜根補(bǔ)充劑進(jìn)一步開展研究,，以判定這一物質(zhì)是否適用于其他臨床試驗(yàn)研究”,，她認(rèn)為人們對(duì)姜根補(bǔ)充劑的關(guān)注度會(huì)越來(lái)越大，因?yàn)槿藗円恢痹趯ふ覠o(wú)毒,、成本效益低,、能提高生活質(zhì)量的預(yù)防癌癥方法。
Zick是傳統(tǒng)醫(yī)學(xué)教育中有關(guān)適當(dāng)運(yùn)用自然療法,、飲食,、營(yíng)養(yǎng)和其他替代療法的四年制自然療法醫(yī)生（ND）。與135所傳統(tǒng)醫(yī)學(xué)學(xué)校所開展的研究項(xiàng)目相比,，她的研究項(xiàng)目?jī)H是全國(guó)8個(gè)研究項(xiàng)目中的一個(gè),。
這項(xiàng)研究由國(guó)家癌癥研究所資助。(生物谷 Bioon.com)
doi:10.1158/1940-6207.CAPR-11-0224
PMC:
PMID:
Phase II Study of the Effects of Ginger Root Extract on Eicosanoids in Colon Mucosa in People at Normal Risk for Colorectal Cancer
Suzanna M. Zick, D. Kim Turgeon, Shaiju K. Vareed, Mack T. Ruffin, Amie J. Litzinger, Benjamin D. Wright, Sara Alrawi, Daniel P. Normolle, Zora Djuric, and Dean E. Brenner.
Inhibitors of COX indicate that upregulation of inflammatory eicosanoids produced by COX, and in particular prostaglandin E2 (PGE2), are early events in the development of colorectal cancer (CRC). Ginger has shown downregulation of COX in vitro and decreased incidence/multiplicity of adenomas in rats. This study was conducted to determine if 2.0 g/d of ginger could decrease the levels of PGE2, 13-hydroxy-octadecadienoic acids, and 5-, 12-, and 15-hydroxyeicosatetraenoic acid (5-, 12-, and 15-HETE), in the colon mucosa of healthy volunteers. To investigate this aim, we randomized 30 subjects to 2.0 g/d ginger or placebo for 28 days. Flexible sigmoidoscopy at baseline and day 28 was used to obtain colon biopsies. A liquid chromatography mass spectrometry method was used to determine eicosanoid levels in the biopsies, and levels were expressed per protein or per free arachidonic acid. There were no significant differences in mean percent change between baseline and day 28 for any of the eicosanoids, when normalized to protein. There was a significant decrease in mean percent change in PGE2 (P = 0.05) and 5-HETE (P = 0.04), and a trend toward significant decreases in 12-HETE (P = 0.09) and 15-HETE (P = 0.06) normalized to free arachidonic acid. There was no difference between the groups in terms of total adverse events P = 0.55). On the basis of these results, it seems that ginger has the potential to decrease eicosanoid levels, perhaps by inhibiting their synthesis from arachidonic acid. Ginger also seemed to be tolerable and safe. Further investigation in people at high risk for CRC seems warranted.
