瑞典卡羅林斯卡醫(yī)學院3月15日對外發(fā)布該學院一項最新研究成果，這一研究顯示,，女性從食物中攝入的鎘元素量與其患乳腺癌的風險正相關,。
這項研究以瑞典近5.6萬名女性參與的飲食習慣調(diào)查數(shù)據(jù)為樣本，經(jīng)分組比對發(fā)現(xiàn),，鎘攝入量最高組的女性比攝入量最低組的女性患乳腺癌風險高21%,。另外，食用全麥食品和蔬菜較多的女性患乳腺癌風險相對較低,。
有關專家認為,，動物肝臟、腎臟以及某些貝類海產(chǎn)品中鎘元素含量相對較高,。研究人員表示,，人們早已知道鎘是有毒物質(zhì)，在某些情況下具有致癌性,，他們開展此項研究的目的在于探求從飲食中攝入的鎘與乳腺癌是否相關,。（生物谷 bioon.com）
doi:10.1158/0008-5472.CAN-11-0735
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Dietary Cadmium Exposure and Risk of Postmenopausal Breast Cancer: A Population-Based Prospective Cohort Study
Bettina Julin, Alicja Wolk, Leif Bergkvist, Matteo Bottai, and Agneta Akesson
The ubiquitous food contaminant cadmium has features of an estrogen mimetic that may promote the development of estrogen-dependent malignancies, such as breast cancer. However, no prospective studies of cadmium exposure and breast cancer risk have been reported. We examined the association between dietary cadmium exposure (at baseline, 1987) and the risk of overall and estrogen receptor (ER)–defined (ER+ or ER?) breast cancer within a population-based prospective cohort of 55,987 postmenopausal women. During an average of 12.2 years of follow-up, 2,112 incident cases of invasive breast cancer were ascertained (1,626 ER+ and 290 ER). After adjusting for confounders, including consumption of whole grains and vegetables (which account for 40% of the dietary exposure, but also contain putative anticarcinogenic phytochemicals), dietary cadmium intake was positively associated with overall breast cancer tumors, comparing the highest tertile with the lowest [rate ratio (RR), 1.21; 95% confidence interval (CI), 1.07–1.36; Ptrend = 0.02]. Among lean and normal weight women, statistically significant associations were observed for all tumors (RR, 1.27; 95% CI, 1.07–1.50) and for ER+ tumors (RR, 1.25; 95% CI, 1.03–1.52) and similar, but not statistically significant associations were found for ER? tumors (RR, 1.22; 95% CI, 0.76–1.93). The risk of breast cancer increased with increasing cadmium exposure similarly within each tertile of whole grain/vegetable consumption and decreased with increasing consumption of whole grain/vegetables within each tertile of cadmium exposure (Pinteraction = 0.73). Overall, these results suggest a role for dietary cadmium in postmenopausal breast cancer development.
