在不同的腫瘤中,，通過干擾RB1信號通路，生長控制失去了正常調(diào)節(jié),。
γ微管蛋白是存于中心體的另一種微管蛋白, γ微管蛋白對微管的形成具有重要作用,。
瑞典蘭德大學(xué)的研究人員最近發(fā)現(xiàn)，RB1及γ微管蛋白通過結(jié)合到它們各自的基因啟動子上,，削弱了彼此的表達(dá),。
而且，同時減少RB1及γ微管蛋白水平,，會導(dǎo)致E2F1依賴的凋亡基因（比如caspase 3）的上調(diào)。
研究發(fā)現(xiàn),，在不同的腫瘤類型,，在RB1及γ微管蛋白的表達(dá)水平有一個負(fù)相關(guān)關(guān)系。在RB1無功能的腫瘤細(xì)胞系,，γ微管蛋白的減少會導(dǎo)致凋亡的誘導(dǎo),。
因此，RB1/γ微管蛋白信號網(wǎng)絡(luò)能夠成為一個新的癌癥治療靶點(diǎn),。相關(guān)論文發(fā)表在4月6日的The Journal of Biological Chemistry,。（生物谷Deepblue編譯）
doi: 10.1074/jbc.M112.357038
PMC:
PMID:
Tumors with non-functional RB1 are killed by reduced gamma-tubulin levels
Asa Ehlen, Catalina A. Rossello, Kristoffer von Stedingk, Greta Hoog, Elise Nilsson, Helen M. Pettersson, Karin Jirstrom and Maria Alvarado-Kristensson.
In various tumors inactivation of growth control is achieved by interfering with the RB1 signaling pathway.Here, we describe that RB1 and γ tubulin proteins moderate each other's expression by binding to their respective gene promoters.Simultaneous reduction of RB1 and γ tubulin protein levels result in an E2F1-dependent upregulation of apoptotic genes such as caspase 3.We report that in various tumors types, there is an inverse correlation between the expression levels of γ tubulin and RB1 and that in tumor cell lines with a non-functioning RB1, reduction of γ tubulin protein levels leads to induction of apoptosis.Thus, the RB1/γ tubulin signal network can be considered as a new target for cancer treatment.
