4月3日,，發(fā)表在Lung Cancer上的一項(xiàng)新研究調(diào)查了超過(guò)1200名亞洲婦女,，發(fā)現(xiàn)每周服用幾次阿司匹林，患肺癌的風(fēng)險(xiǎn)要低得多——不管她們是否吸煙,。該研究認(rèn)為阿司匹林可降低風(fēng)險(xiǎn)50%以上,，但不能證明阿司匹林有直接對(duì)抗肺癌的作用。但是他們支持其他研究顯示的常規(guī)阿司匹林使用和特定癌癥風(fēng)險(xiǎn)降低的關(guān)聯(lián),，包括結(jié)腸癌,、前列腺癌和食管癌。
盡管如此,，專(zhuān)家們說(shuō)推薦廣泛服用阿司匹林降低癌癥風(fēng)險(xiǎn)還為時(shí)尚早,。阿司匹林是否對(duì)抗肺癌的問(wèn)題仍然需要討論，目前公布的證據(jù)還不能定論,。
這項(xiàng)研究納入了398名診斷為肺癌的中國(guó)女性,，和814名沒(méi)有癌癥的婦女。研究發(fā)現(xiàn)那些定期服用阿司匹林的女性（一周至少2次,，持續(xù)1月以上）,，肺癌風(fēng)險(xiǎn)降低。
研究人員調(diào)整了其他因素,，包括年齡,、教育程度和水果蔬菜攝入量,。但應(yīng)該仍存在其他因素可以幫助解釋阿司匹林為什么可以降低肺癌風(fēng)險(xiǎn)。
阿司匹林使用者和非使用者之間癌癥風(fēng)險(xiǎn)的相對(duì)差異較大,，但是對(duì)于個(gè)人絕對(duì)風(fēng)險(xiǎn)的降低可能比較小,。
Andrew T. Chan博士沒(méi)有參與這項(xiàng)研究，他講到,，阿司匹林和肺癌之間關(guān)聯(lián)的證據(jù)比較混雜,，阿司匹林可預(yù)防結(jié)腸癌的證據(jù)較強(qiáng)。我不認(rèn)為本研究的證據(jù)比較明確,，推薦所有中年人和老年人每日服用阿司匹林還尚早,。
但是醫(yī)生和患者討論低劑量阿司匹林的利弊是很合理的，人們通常對(duì)預(yù)防多種腫瘤更感興趣,，但是也需要了解阿司匹林的風(fēng)險(xiǎn),。（生物谷Bioon.com）
doi:10.1016/j.lungcan.2012.03.005
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Aspirin and non-aspirin non-steroidal anti-inflammatory drug use and risk of lung cancer
Wei-Yen Lima, , , Khoon Leong Chuahb, Philip Engc, Swan Swan Leongd, Elaine Limb, Tow Keang Lime, Alan Ngb, Wee Teng Pohf, Augustine Teef, Ming Tehe, Agus Salima, Adeline Seowa
There is evidence that aspirin and non-aspirin non-steroidal anti-inflammatory drug (NSAID) have anti-carcinogenic properties, but their effect on lung cancer, in particular in never-smokers, is unclear. Information on past or current use of anti-inflammatory medication was obtained in 398 Chinese female primary lung cancer cases and 814 controls in a hospital-based study in Singapore. 65% of cases and 88% of controls were never-smokers. Controls were excluded if they had been admitted for conditions associated with aspirin or NSAID use (n = 174). Regular aspirin use (twice a week or more, for a month or more) was associated with a reduced risk of lung cancer (adjusted odds ratio [OR] 0.50, 95% confidence intervals [95%CI] 0.31–0.81 in non-smokers; OR 0.38, 95%CI 0.16–0.93 in smokers). Regular use of non-aspirin NSAID, paracetamol, steroid creams and steroid pills was uncommon and no association with lung cancer was detected. Our results suggest that aspirin consumption may reduce lung cancer risk in Asian women and are consistent with current understanding of the role of cyclooxygenase in lung carcinogenesis.
