近日,，來自米利亞姆醫(yī)院的研究者運用一種新的綜合分析技術分析表明,，II型糖尿病病人存在20%患血癌的風險，比如非霍奇金淋巴瘤,、白血病和骨髓瘤,。這項研究刊登在了國際著名雜志Blood上，研究數(shù)據(jù)為糖尿病和特定類型的癌癥之間的聯(lián)系提供了證據(jù),。
研究者Jorge Castillo表示,，大多數(shù)人只認為心臟疾病、腎衰竭和糖尿病直接相關,，然而在超過1900萬被診斷患有糖尿病的美國人中患血癌等風險比例提高了20%,。以前的研究表明，糖尿病和肝癌,、胰腺癌有關系,，很少有研究揭示血癌和糖尿病之間的關系,。
研究者分析了26篇科學家發(fā)表的關于II型糖尿病和淋巴瘤、白血病關系的相關研究論文,，而后研究者又對時間范圍內(nèi)超過17000名II型糖尿病患者和血癌患者進行整合分析,。最后總結道，II型糖尿病患者患白血病,、骨髓瘤以及非霍奇金淋巴瘤的風險明顯增加,，更有意思的是，研究者發(fā)現(xiàn)患淋巴瘤,、骨髓瘤以及白血病的患者會因地區(qū)不同,，其發(fā)病風險也不盡相同，比如,，非霍奇金淋巴瘤在亞洲和歐洲比較高發(fā),，而白血病在美國和亞洲比較高發(fā)。
研究并沒有發(fā)現(xiàn)為什么II型糖尿病為什么和這些疾病相關,，研究者表示,，他們后期還會進行一些深入研究來解釋II型糖尿病和血癌之間的潛在關系。Castillo后期會重點研究肥胖,、物理活動,、抽煙相關的行為因素，這些都和糖尿病,、癌癥有一定的關系,。相關研究由國立衛(wèi)生研究院提供資助。（生物谷Bioon.com）
編譯自：Type 2 Diabetes Linked to Increased Blood Cancer Risk
編譯者：T.Shen
doi:10.1182/blood-2011-06-362830
PMC:
PMID:
Increased incidence of non-Hodgkin lymphoma, leukemia, and myeloma in patients with diabetes mellitus type 2: a meta-analysis of observational studies
Jorge J. Castillo1, Nikhil Mull2, John L. Reagan1, Saed Nemr2, and Joanna Mitri3
Hematologic malignancies are a heterogeneous group of conditions with an unclear etiology. We hypothesized that diabetes mellitus type 2 is associated with increased risk of developing lymphoma, leukemia, and myeloma. A literature search identified 26 studies (13 case-control and 13 cohort studies) evaluating such an association. Outcome was calculated as the odds ratio (OR) using a random effects model. Heterogeneity and publication bias were evaluated using the I2 index and the trim-and-fill analysis, respectively. Quality was assessed using the Newcastle-Ottawa scale. The OR for non-Hodgkin lymphoma was increased at 1.22 (95% confidence interval [CI], 1.07-1.39; P < .01) but the OR for Hodgkin lymphoma was not. There was an increased OR for peripheral T-cell lymphoma (OR = 2.42, 95% CI, 1.24-4.72; P = .009) but not for other non-Hodgkin lymphoma subtypes. The OR for leukemia was 1.22 (95% CI, 1.03-1.44; P = .02) and the OR for myeloma was 1.22 (95% CI, 0.98-1.53; P = .08). Although diabetes mellitus type 2 seems to increase the risk of developing lymphoma, leukemia, and myeloma, future studies should focus on evaluating other potential confounders such as obesity, dietary habits, physical activity, and/or antidiabetic therapy.
