近日,，一項刊登在Archives of Dermatology雜志上的研究證實：吸煙似乎與皮膚鱗狀細胞癌皮膚癌的風險增加有關。
無論是基底細胞癌（基底細胞癌）或鱗狀細胞癌（鱗癌）還是非黑色素瘤皮膚癌（NMSC）,，約97％的皮膚癌起源于上皮細胞（包括皮膚細胞）。在世界范圍內NMSC的發(fā)病率不斷增加,，每年估計有200萬到300萬的新發(fā)病例,。
英國煙草控制研究中心、英國諾丁漢大學Jo Leonardi-Bee博士和他的同事納入25項研究,，對吸煙與皮膚鱗狀細胞癌風險之間的關系進行了分析研究,。這個系統(tǒng)回顧和薈萃分析研究結果顯示吸煙和皮膚鱗狀細胞癌之間有密切關系，吸煙會導致皮膚鱗狀細胞癌風險增加52％,。
研究人員得出結論認為：這項研究非常具有臨床重要性,，為識別早期皮膚癌，及早診斷并采取預防措施可明顯改善患者預后情況。（生物谷：Bioon.com）
doi:10.1001/archdermatol.2012.1374
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Smoking and the Risk of Nonmelanoma Skin CancerSystematic Review and Meta-analysis
Jo Leonardi-Bee, PhD; Thomas Ellison, BMedSci; Fiona Bath-Hextall, PhD
Objective To perform a systematic review and meta-analysis to collate evidence of the effects of smoking on the risk of nonmelanoma skin cancer.
Data Sources We searched 4 electronic databases (from inception to October 2010) and scanned the reference lists of the publications retrieved to identify eligible comparative epidemiologic studies.
Study Selection Titles, abstracts, and full text were assessed independently by 2 authors against prespecified inclusion/exclusion criteria.
Data Extraction Data were extracted and quality was assessed independently by 2 authors using the Newcastle-Ottawa Scale.
Data Synthesis Meta-analysis was performed using random-effects models. Results are presented as odds ratios (ORs) with 95% CIs. Heterogeneity was assessed using I2. Twenty-five studies were included. Smoking was significantly associated with cutaneous squamous cell carcinoma (OR, 1.52; 95% CI, 1.15-2.01; I2 = 64%; 6 studies). Smoking was not significantly associated with basal cell carcinoma (OR, 0.95; 95% CI, 0.82-1.09; I2 = 59%; 14 studies) or nonmelanoma skin cancer (OR, 0.62; 95% CI, 0.21-1.79; I2 = 34%; 2 studies).
Conclusion This study clearly demonstrates that smoking increases the risk of cutaneous squamous cell carcinoma; however, smoking does not appear to modify the risk of basal cell carcinoma.
