姜黃(Curcuma longa)是姜科植物姜黃的根莖,，姜黃不僅在印度作為香料用于食品咖喱中，而且在中國具有悠久的藥用歷史,，其性味辛,、苦、溫,可行氣破瘀,、通經(jīng)止痛,。姜黃主要成分姜黃素具有廣泛的藥理作用，而對于姜黃素抗腫瘤作用的研究,，長期以來主要集中在腫瘤的化學(xué)預(yù)防方面,。隨著現(xiàn)代分子生物學(xué)研究的不斷發(fā)展，研究者們對姜黃素作用機(jī)制有了更深入的研究,。
雖然已有大量文獻(xiàn)證實(shí)姜黃素可以防止癌變,，抑制腫瘤的發(fā)展。然而,，很少有人知道姜黃素的抗小細(xì)胞肺癌（SCLC）的具體機(jī)制,。近日刊登在PLoS One雜志上的一項(xiàng)研究證實(shí)：姜黃素可以通過抑制STAT3的表達(dá)，進(jìn)而抑制小細(xì)胞肺癌細(xì)胞增殖,、影響腫瘤細(xì)胞的細(xì)胞周期,，降低細(xì)胞遷移、侵襲和血管生成,。
小細(xì)胞肺癌細(xì)胞經(jīng)15μmol/ L的姜黃素處理后,，姜黃素能有效抑制STAT3的磷酸化，下調(diào)STAT3的下游調(diào)控蛋白,，這有助于抑制細(xì)胞的增殖,，細(xì)胞集落形成能力減弱,，細(xì)胞遷移和侵襲能力也降低。
姜黃素抑制增殖蛋白（Survivin,、BCL-X和Cyclin B1）,、VEGF、MMP-2,，MMP-7和ICAM-1的表達(dá),。siRNA沉默STAT3的表達(dá)也能降低腫瘤細(xì)胞體外侵襲能力。相比之下,，白細(xì)胞介素6（IL-6）激活STAT3增加細(xì)胞增殖,，促進(jìn)細(xì)胞的存活，血管生成,、侵襲,、遷移和腫瘤的生長也升高。
研究人員得出的結(jié)論是姜黃素是一種具有抑制STAT3活性的藥物,，姜黃素可能作為一種有效的治療或預(yù)防小細(xì)胞肺癌的潛在藥物,。（生物谷：Bioon.com）
doi:10.1371/journal.pone.0037960
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Curcumin Blocks Small Cell Lung Cancer Cells Migration, Invasion, Angiogenesis, Cell Cycle and Neoplasia through Janus Kinase-STAT3 Signalling Pathway.
Yang CL, Liu YY, Ma YG, Xue YX, Liu DG, Ren Y, Liu XB, Li Y, Li Z.
Curcumin, the active component of turmeric, has been shown to protect against carcinogenesis and prevent tumor development. However, little is known about its anti-tumor mechanism in small cell lung cancer (SCLC). In this study, we found that curcumin can inhibit SCLC cell proliferation, cell cycle, migration, invasion and angiogenesis through suppression of the STAT3. SCLC cells were treated with curcumin (15 µmol/L) and the results showed that curcumin was effective in inhibiting STAT3 phosphorylation to downregulate of an array of STAT3 downstream targets ,which contributed to suppression of cell proliferation, loss of colony formation, depression of cell migration and invasion. Curcumin also suppressed the expression of proliferative proteins (Survivin, Bcl-X(L) and Cyclin B1), and invasive proteins (VEGF, MMP-2, MMP-7 and ICAM-1).Knockdown of STAT3 expression by siRNA was able to induce anti-invasive effects in vitro. In contrast, activation of STAT3 upstream of interleukin 6 (IL-6) leads to the increased cell proliferation ,cell survival, angiogenesis, invasion, migration and tumor growth. Our findings illustrate the biologic significance of IL-6/JAK/STAT3 signaling in SCLC progression and providenovel evidence that the pathway may be a new potential target for therapy of SCLC. It was concluded that curcumin is a potent agent in the inhibition of STAT3 with favorable pharmacological activity,and curcumin may have translational potential as an effective cancer therapeutic or preventive agent for SCLC.
