近日，來自昆士蘭大學(xué)的研究者發(fā)現(xiàn)了蛋白如何通過膠水粘連細(xì)胞共同作用形成健康組織的重要的步驟,，在癌癥和炎癥病人中,，這個過程被破壞掉了。文章中研究者發(fā)現(xiàn)了一種關(guān)鍵信號,，這種信號可以促使蛋白質(zhì)產(chǎn)生“膠水”然后結(jié)合細(xì)胞形成健康組織,，相關(guān)研究成果刊登在了近日的國際雜志Nature Cell Biology上。
研究者Yap表示，細(xì)胞是構(gòu)筑我們機體最基本的單元,，健康的組織需要足夠的細(xì)胞粘連來維持，而且這種黏著作用需要通過特殊的束狀蛋白質(zhì)來完成,，束狀蛋白質(zhì)的形成依托于信號蛋白Rho的促進,。這種信號就好比是管弦樂隊的指揮者一樣，確保整個樂隊各個成員的發(fā)揮正常,。
細(xì)胞網(wǎng)絡(luò)中很多蛋白質(zhì)都參與了癌癥的發(fā)病,，研究者的這項研究發(fā)現(xiàn)意味著可以為健康組織的形成提供一些思路。這項研究由人類前沿科學(xué)計劃支持,。（生物谷Bioon.com）
編譯自：Cell glue gives insights into cancer
doi:10.1038/ncb2532
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Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens
Aparna Ratheesh,1, 4 Guillermo A. Gomez,1, 4 Rashmi Priya,1 Suzie Verma,1 Eva M. Kovacs,1 Kai Jiang,2 Nicholas H. Brown,3 Anna Akhmanova,2 Samantha J. Stehbens1, 5 & Alpha S. Yap1
The biological impact of Rho depends critically on the precise subcellular localization of its active, GTP-loaded form. This can potentially be determined by the balance between molecules that promote nucleotide exchange or GTP hydrolysis. However, how these activities may be coordinated is poorly understood. We now report a molecular pathway that achieves exactly this coordination at the epithelial zonula adherens. We identify an extramitotic activity of the centralspindlin complex, better understood as a cytokinetic regulator, which localizes to the interphase zonula adherens by interacting with the cadherin-associated protein, α-catenin. Centralspindlin recruits the RhoGEF, ECT2, to activate Rho and support junctional integrity through myosin IIA. Centralspindlin also inhibits the junctional localization of p190 B RhoGAP, which can inactivate Rho. Thus, a conserved molecular ensemble that governs Rho activation during cytokinesis is used in interphase cells to control the Rho GTPase cycle at the zonula adherens.
