7月22日,，Nature雜志在線報(bào)道，染色質(zhì)組織方式對人類癌細(xì)胞中區(qū)域性突變率具有重大影響,。
癌癥基因組測序,，提供了人類體細(xì)胞整個(gè)基因組的基因突變率差異的第一手資料,。通過檢測各種遺傳學(xué)和表觀遺傳學(xué)指標(biāo)，研究者發(fā)現(xiàn),，癌癥細(xì)胞基因組的基因突變率與染色質(zhì)組織方式存在驚人的相關(guān)性,。
事實(shí)上，在百萬堿基數(shù)量級上,，一個(gè)單一的染色質(zhì)組織特性（異染色質(zhì)相關(guān)組蛋白修飾H3K9me3的水平）,，可以導(dǎo)致40％以上的突變率的變化。而一系列染色質(zhì)組織特性的組合因素更可導(dǎo)致55％以上的突變率的變化,。
突變率和染色質(zhì)組織之間的強(qiáng)烈相關(guān)性,，在來源于不同組織的樣本中，以及不同類型的突變中,，均得到了證實(shí),。這表明將基因組序列組織成異染色質(zhì)和常染色質(zhì)樣高級結(jié)構(gòu)的方式，是人體細(xì)胞區(qū)域性突變率差異的主導(dǎo)因素,。（生物谷bioon.com）
doi:10.1016/j.cell.2011.10.017
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Chromatin organization is a major influence on regional mutation rates in human cancer cells
Benjamin Schuster-B?ckler& Ben Lehner
Cancer genome sequencing provides the first direct information on how mutation rates vary across the human genome in somatic cells1, 2, 3, 4, 5, 6, 7. Testing diverse genetic and epigenetic features, here we show that mutation rates in cancer genomes are strikingly related to chromatin organization. Indeed, at the megabase scale, a single feature—levels of the heterochromatin-associated histone modification H3K9me3—can account for more than 40% of mutation-rate variation, and a combination of features can account for more than 55%. The strong association between mutation rates and chromatin organization is upheld in samples from different tissues and for different mutation types. This suggests that the arrangement of the genome into heterochromatin- and euchromatin-like domains is a dominant influence on regional mutation-rate variation in human somatic cells.
