2012年8月28日 訊 /生物谷BIOON/ --缺乏睡眠與乳腺癌更具侵襲性存在聯(lián)系，據(jù)一項(xiàng)新的發(fā)表在八月Breast Cancer Research and Treatment雜志上的研究證實(shí),。
該項(xiàng)研究在Cheryl Thompson博士的帶領(lǐng)下，首次證實(shí)睡眠不足和腫瘤的更具侵略性和癌癥復(fù)發(fā)有關(guān),。該研究小組分析了412名絕經(jīng)后乳腺癌患者，在研究開始時(shí)所有患者均被招募進(jìn)行診斷,，并調(diào)查她們在過去兩年內(nèi)的平均睡眠時(shí)間,。
研究人員發(fā)現(xiàn)，平均每晚睡眠6小時(shí)或更少的女性乳腺癌的診斷有較高的安可待(Oncotype DX)復(fù)發(fā)分?jǐn)?shù),。 安可待(Oncotype DX)是乳癌腫瘤基因分子檢測項(xiàng)目,，主要是檢測乳癌腫瘤組織中21個(gè)不同基因的表現(xiàn)。
凱斯西儲(chǔ)大學(xué)醫(yī)學(xué)助理教授Thompson博士說：這是首次有研究表明,，與睡眠時(shí)間更長的女性相比,，那些經(jīng)常睡眠時(shí)間不足的婦女更有可能發(fā)展患有更具侵襲性的乳癌。 我們發(fā)現(xiàn)每晚睡眠時(shí)間少和復(fù)發(fā)得分高有很強(qiáng)的相關(guān)性,，特別是對那些絕經(jīng)后乳腺癌患者來說,。這表明，缺乏充足的睡眠可能會(huì)導(dǎo)致腫瘤更具侵略性,，但需要做更多的研究來驗(yàn)證這一發(fā)現(xiàn),，并開展相關(guān)研究來了解這種關(guān)聯(lián)的原因。
凱斯西儲(chǔ)大學(xué)醫(yī)學(xué)院流行病學(xué)和生物統(tǒng)計(jì)學(xué)醫(yī)學(xué)博士Li Li說：睡眠時(shí)間短是危害公眾健康的主要原因之一,，這會(huì)導(dǎo)致肥胖,、糖尿病和心臟疾病等問題。通過有效干預(yù)來增加睡眠時(shí)間,，提高睡眠質(zhì)量來降低乳腺癌發(fā)展成成更具侵襲性以及降低復(fù)發(fā)的風(fēng)險(xiǎn)可能是有效的手段之一,。（生物谷：Bioon.com）
doi:10.1007/s10549-012-2144-z
PMC:
PMID:
Association of sleep duration and breast cancer OncotypeDX recurrence score
Cheryl L. Thompson, Li Li
Shorter duration of sleep has been associated with risk of a number of medical conditions, including breast cancer. However, no prior study has investigated the relationship of average sleep duration before diagnosis and cancer aggressiveness. OncotypeDX is a widely utilized test to guide treatment in early stage hormone receptor positive breast cancer by predicting likelihood of recurrence. We reviewed medical records from ER+ early stage breast cancer patients participating in a case–control study for availability of OncotypeDX scores. All patients in the parent study were recruited at diagnosis and asked about average sleep duration in the 2 years before diagnosis. We analyzed data from 101 breast cancer patients with available OncotypeDX recurrence scores to test the hypothesis that shorter sleep is associated with greater likelihood of recurrence. We found that OncotypeDX recurrence scores were strongly correlated with average hours of sleep per night before breast cancer diagnosis, with fewer hours of sleep associated with a higher (worse) recurrence score (R = −0.30, p = 0.0031). This correlation was limited to post-menopausal breast cancer patients only (R = −0.41, p = 0.0011, for postmenopausal patients; R = −0.05, p = 0.80 for pre-menopausal patients). This association remains statistically significant after adjustment for age, physical activity, smoking status, and body mass index in the entire study sample (p = 0.0058) as well as in postmenopausal patients (p = 0.0021). This is the first study to suggest that women who routinely sleep fewer hours may develop more aggressive breast cancers compared with women who sleep longer hours.
