2012年8月28日 訊 /生物谷BIOON/ --缺乏睡眠與乳腺癌更具侵襲性存在聯(lián)系,，據(jù)一項新的發(fā)表在八月Breast Cancer Research and Treatment雜志上的研究證實。
該項研究在Cheryl Thompson博士的帶領下,，首次證實睡眠不足和腫瘤的更具侵略性和癌癥復發(fā)有關,。該研究小組分析了412名絕經(jīng)后乳腺癌患者，在研究開始時所有患者均被招募進行診斷,，并調(diào)查她們在過去兩年內(nèi)的平均睡眠時間,。
研究人員發(fā)現(xiàn)，平均每晚睡眠6小時或更少的女性乳腺癌的診斷有較高的安可待(Oncotype DX)復發(fā)分數(shù),。 安可待(Oncotype DX)是乳癌腫瘤基因分子檢測項目,，主要是檢測乳癌腫瘤組織中21個不同基因的表現(xiàn),。
凱斯西儲大學醫(yī)學助理教授Thompson博士說：這是首次有研究表明,，與睡眠時間更長的女性相比，那些經(jīng)常睡眠時間不足的婦女更有可能發(fā)展患有更具侵襲性的乳癌,。 我們發(fā)現(xiàn)每晚睡眠時間少和復發(fā)得分高有很強的相關性,，特別是對那些絕經(jīng)后乳腺癌患者來說。這表明,，缺乏充足的睡眠可能會導致腫瘤更具侵略性,，但需要做更多的研究來驗證這一發(fā)現(xiàn)，并開展相關研究來了解這種關聯(lián)的原因,。
凱斯西儲大學醫(yī)學院流行病學和生物統(tǒng)計學醫(yī)學博士Li Li說：睡眠時間短是危害公眾健康的主要原因之一,，這會導致肥胖、糖尿病和心臟疾病等問題,。通過有效干預來增加睡眠時間,，提高睡眠質(zhì)量來降低乳腺癌發(fā)展成成更具侵襲性以及降低復發(fā)的風險可能是有效的手段之一。（生物谷：Bioon.com）
doi:10.1007/s10549-012-2144-z
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PMID:
Association of sleep duration and breast cancer OncotypeDX recurrence score
Cheryl L. Thompson, Li Li
Shorter duration of sleep has been associated with risk of a number of medical conditions, including breast cancer. However, no prior study has investigated the relationship of average sleep duration before diagnosis and cancer aggressiveness. OncotypeDX is a widely utilized test to guide treatment in early stage hormone receptor positive breast cancer by predicting likelihood of recurrence. We reviewed medical records from ER+ early stage breast cancer patients participating in a case–control study for availability of OncotypeDX scores. All patients in the parent study were recruited at diagnosis and asked about average sleep duration in the 2 years before diagnosis. We analyzed data from 101 breast cancer patients with available OncotypeDX recurrence scores to test the hypothesis that shorter sleep is associated with greater likelihood of recurrence. We found that OncotypeDX recurrence scores were strongly correlated with average hours of sleep per night before breast cancer diagnosis, with fewer hours of sleep associated with a higher (worse) recurrence score (R = −0.30, p = 0.0031). This correlation was limited to post-menopausal breast cancer patients only (R = −0.41, p = 0.0011, for postmenopausal patients; R = −0.05, p = 0.80 for pre-menopausal patients). This association remains statistically significant after adjustment for age, physical activity, smoking status, and body mass index in the entire study sample (p = 0.0058) as well as in postmenopausal patients (p = 0.0021). This is the first study to suggest that women who routinely sleep fewer hours may develop more aggressive breast cancers compared with women who sleep longer hours.
