2012年9月13日 訊 /生物谷BIOON/ --在一項(xiàng)新研究中,，來(lái)自美國(guó)南加州大學(xué)的研究人員首次證實(shí)控制性禁食(controlled fasting)改善在癌癥治療中的化療療效,，延長(zhǎng)患有侵襲性腦瘤的小鼠的預(yù)期壽命。
在這項(xiàng)刊登在PLoS ONE期刊上的最新研究中,，研究人員首次證實(shí)禁食時(shí)間似乎提高化療在治療神經(jīng)膠質(zhì)瘤上的療效,。神經(jīng)膠質(zhì)瘤是一種最為常見被診斷出來(lái)的腦瘤?；加猩窠?jīng)膠質(zhì)瘤的病人平均存活期限小于兩年,。
論文通信作者Valter Longo和他的同事們研究了禁食與化療以及禁食與化療藥物替莫唑胺(Temozolomide)組合使用的療效。他們發(fā)現(xiàn)對(duì)小鼠進(jìn)行控制性短期禁食,，每個(gè)治療周期不超過(guò)48個(gè)小時(shí),，能夠改善化療和化療在治療神經(jīng)膠質(zhì)瘤中的療效。即便所研究的腦瘤能夠極其侵襲性地生長(zhǎng),，參加禁食和接受化療治療的小鼠在治療結(jié)束時(shí)存活的數(shù)量是只參加禁食或只接受化療治療的那些小鼠的兩倍多,。
這些研究結(jié)果證實(shí)禁食和標(biāo)準(zhǔn)化療與放療在治療神經(jīng)膠質(zhì)瘤中發(fā)揮出有益性作用。(生物谷Bioon.com)
doi: 10.1371/journal.pone.0044603
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Fasting Enhances the Response of Glioma to Chemo- and Radiotherapy
Fernando Safdie1#, Sebastian Brandhorst1,4#, Min Wei1, Weijun Wang2, Changhan Lee1, Saewon Hwang1, Peter S. Conti3, Thomas C. Chen2, Valter D. Longo
Background
Glioma, including anaplastic astrocytoma and glioblastoma multiforme (GBM) are among the most commonly diagnosed malignant adult brain tumors. GBM is a highly invasive and angiogenic tumor, resulting in a 12 to 15 months median survival. The treatment of GBM is multimodal and includes surgical resection, followed by adjuvant radio-and chemotherapy. We have previously reported that short-term starvation (STS) enhances the therapeutic index of chemo-treatments by differentially protecting normal cells against and/or sensitizing tumor cells to chemotoxicity.
Methodology and Principal Findings
To test the effect of starvation on glioma cells in vitro, we treated primary mouse glia, murine GL26, rat C6 and human U251, LN229 and A172 glioma cells with Temozolomide in ad lib and STS mimicking conditions. In vivo, mice with subcutaneous or intracranial models of GL26 glioma were starved for 48 hours prior to radio- or chemotherapy and the effects on tumor progression and survival were measured. Starvation-mimicking conditions sensitized murine, rat and human glioma cells, but not primary mixed glia, to chemotherapy. In vivo, starvation for 48 hours, which causes a significant reduction in blood glucose and circulating insulin-like growth factor 1 (IGF-1) levels, sensitized both subcutaneous and intracranial glioma models to radio-and chemotherapy.
Conclusion
Starvation-induced cancer sensitization to radio- or chemotherapy leads to extended survival in the in vivo glioma models tested. These results indicate that fasting and fasting-mimicking interventions could enhance the efficacy of existing cancer treatments against aggressive glioma in patients.
