一種用于檢測腫瘤中非放射性葡萄糖分子攝入情況的無損技術(shù)能幫助診斷癌癥類型并評估病人的治療反應(yīng),，這是8月《自然—醫(yī)學(xué)》上一項研究給出的結(jié)論,。
與正常組織相比，腫瘤需要攝入更多的葡萄糖以產(chǎn)生能量和制造細(xì)胞增殖所需的阻斷物,。Simon Walker-Samuel等人開發(fā)的這項技術(shù)被稱為葡萄糖化學(xué)交換飽和轉(zhuǎn)移（glucoCEST）,，同其他黃金標(biāo)準(zhǔn)技術(shù)以及諸如缺氧之類的腫瘤代謝標(biāo)記相比，該技術(shù)在測定腫瘤的攝入葡萄糖代謝方面具有很高的靈敏性,。他們已用該技術(shù)確定出了含有不同致命結(jié)構(gòu)的多種結(jié)直腸腫瘤類型,。
因為該技術(shù)已被證明與其他放射性檢測技術(shù)具有相同的效果，而該技術(shù)使用的是未標(biāo)記的葡萄糖,，這將使臨床應(yīng)用成本更便宜,、使用更簡便。研究人員相信,，這項新技術(shù)也能用于鑒定腫瘤內(nèi)的細(xì)胞變異情況,，從而影響治療過程中的藥物反應(yīng)，同時還能用于較小腫瘤的評估,。（生物谷 Bioon.com）
生物谷推薦的英文摘要
Nature Medicine doi:10.1038/nm.3252
In vivo imaging of glucose uptake and metabolism in tumors
Simon Walker-Samuel, Rajiv Ramasawmy, Francisco Torrealdea, Marilena Rega, Vineeth Rajkumar, S Peter Johnson, Simon Richardson, Miguel Gonçalves, Harold G Parkes, Erik Årstad, David L Thomas, R Barbara Pedley, Mark F Lythgoe & Xavier Golay
Tumors have a greater reliance on anaerobic glycolysis for energy production than normal tissues. We developed a noninvasive method for imaging glucose uptake in vivo that is based on magnetic resonance imaging and allows the uptake of unlabeled glucose to be measured through the chemical exchange of protons between hydroxyl groups and water. This method differs from existing molecular imaging methods because it permits detection of the delivery and uptake of a metabolically active compound in physiological quantities. We show that our technique, named glucose chemical exchange saturation transfer (glucoCEST), is sensitive to tumor glucose accumulation in colorectal tumor models and can distinguish tumor types with differing metabolic characteristics and pathophysiologies. The results of this study suggest that glucoCEST has potential as a useful and cost-effective method for characterizing disease and assessing response to therapy in the clinic.
