對(duì)來(lái)自19個(gè)不同癌癥類型的超過(guò)4000個(gè)腫瘤所做的一項(xiàng)分析評(píng)估了病毒在造成這種疾病中所起作用。發(fā)表在本期Nature Communications上的這項(xiàng)研究,，為了解病毒在腫瘤形成中所起作用提供了一個(gè)綜合性數(shù)據(jù)集,。
Erik Larsson及同事利用來(lái)自“癌癥基因組圖譜”的數(shù)據(jù)檢測(cè)來(lái)自19個(gè)不同癌癥亞型的4438個(gè)腫瘤中是否存在病毒核酸，發(fā)現(xiàn)178個(gè)腫瘤含有病毒RNA,。他們證實(shí)了宮頸癌中“人乳頭狀病毒”的存在,，也證實(shí)了肝細(xì)胞癌中乙肝病毒的存在。然而,，他們沒(méi)有在乳腺癌或“多形性膠質(zhì)母細(xì)胞瘤”（腦癌）中檢測(cè)到病毒的存在,，這兩種癌癥過(guò)去都曾被認(rèn)為是由病毒引起的。這些數(shù)據(jù)覆蓋一系列不同的腫瘤,，包括膀胱,、結(jié)腸、大腦,、腎臟,、皮膚、卵巢,、前列腺、甲狀腺,、直腸和肺的腫瘤,。他們發(fā)現(xiàn)，7.3%的膀胱癌,、9.8%的結(jié)腸癌,、14.8%的頭部和頸部癌以及5.6%的直腸癌都含有病毒RNA，說(shuō)明病毒在這些腫瘤的一小部分（的發(fā)?。┊?dāng)中可能扮演一定角色,。
這些發(fā)現(xiàn)提供了有關(guān)腫瘤中病毒之存在的最大規(guī)模的分析結(jié)果，排除了病毒在腫瘤形成中起廣泛作用的可能性,。(生物谷Bioon.com）
生物谷推薦的英文摘要
Nature Communications doi:10.1038/ncomms3513
The landscape of viral expression and host gene fusion and adaptation in human cancer
Ka-Wei Tang,Babak Alaei-Mahabadi,Tore Samuelsson,Magnus Lindh& Erik Larsson
Viruses cause 10–15% of all human cancers. Massively parallel sequencing has recently proved effective for uncovering novel viruses and virus–tumour associations, but this approach has not yet been applied to comprehensive patient cohorts. Here we screen a diverse landscape of human cancer, encompassing 4,433 tumours and 19 cancer types, for known and novel expressed viruses based on >700 billion transcriptome sequencing reads from The Cancer Genome Atlas Research Network. The resulting map confirms and extends current knowledge. We observe recurrent fusion events, including human papillomavirus insertions in RAD51B and ERBB2. Patterns of coadaptation between host and viral gene expression give clues to papillomavirus oncogene function. Importantly, our analysis argues strongly against viral aetiology in several cancers where this has frequently been proposed. We provide a virus–tumour map of unprecedented scale that constitutes a reference for future studies of tumour-associated viruses using transcriptome sequencing data.
