最近來自于以色列的一項研究表明，超重的未成年人罹患食管癌的概率是體重正常者的兩倍,，該項研究成果發(fā)表在美國癌癥協(xié)會同行評審期刊《癌癥》（Cancer）上,，他們還發(fā)現(xiàn)較低的社會經(jīng)濟地位以及生活在高患癌風(fēng)險的國家是未來患胃癌的決定因素,。
Zohar Levi來自于以色列Rabin醫(yī)學(xué)研究中心，他和他的同事在1967-2005年間測量了100萬名平均年齡為17歲的未成年男性的的體重指數(shù)，并通過國家癌癥注冊中心,，確定了哪一類人群更容易患癌癥,。參與者跟蹤實驗的時間從2.5年到40年不等，平均為跟蹤時間為18.8年,。
研究者們驚奇的發(fā)現(xiàn)17歲之前的生活狀態(tài)——尤其是體重和社會經(jīng)濟地位——和未來癌癥的發(fā)病率有很大的相關(guān)性,。超重的未成年人在以后患食管癌的概率是正常體重者的2.1倍。社會經(jīng)濟地位低的未成年人在以后患腸型胃癌的概率高出2.2倍,。接受教育低于9年的人群患癌的概率要高出1.9倍,。另外，從亞洲和前蘇聯(lián)移民去以色列的人有更高的癌癥患病率（分別為3.0倍和2.28倍的高出風(fēng)險）,。
“那些超重的或者肥胖的未成年人更容易罹患食管癌,。另外，社會經(jīng)濟地位較低的人會更容易罹患胃癌”,，Lewi博士說，“從心血管的角度看,，40歲以上的人如果肥胖是很危險的,，但是我們發(fā)現(xiàn)肥胖對人的影響在早年的時候就顯現(xiàn)出來了。”但是Lewi博士指出,，現(xiàn)在肥胖的或者社會經(jīng)濟地位較低的人在減肥之后或者獲得較高的經(jīng)濟地位之后能不能降低患癌的風(fēng)險尚未可知,。(生物谷Bioon.com)
生物谷推薦的英文原文
Cancer DOI: 10.1002/cncr.28241
Body mass index and socioeconomic status measured in adolescence, country of origin and the incidence of gastroesophageal adenocarcinoma in a cohort of 1 million men.
Zohar Levi, Jeremy D. Kark, Ari Shamiss, Estela Derazne, Dorit Tzur, Lital Keinan-Boker, Irena Liphshitz, Yaron Niv, Moshe Furman, and Arnon Afek
Overweight adolescents were twice as likely as their normal weight peers to later develop esophageal cancer in a recent study from Israel. The study, which is published early online in CANCER, a peer-reviewed journal of the American Cancer Society, also found that lower socioeconomic status as well as immigration from higher risk countries were important determinants of gastric cancer.
Zohar Levi, MD, MHA, of the Rabin Medical Center in Israel, and his colleagues measured body mass index in one million Israeli adolescent males who underwent a general health examination at an average age of 17 years from 1967 to 2005, and through the country’s cancer registry, identified which of the participants later developed cancer. Participants were followed from 2.5 to almost 40 years, with an average follow-up of 18.8 years.
The researchers were amazed to find that events—particularly weight and socioeconomic status—up to the age of 17 years had a tremendous impact upon cancer development later in life. Adolescents who were overweight had a 2.1-fold increased risk of developing esophageal cancer. Adolescents who were of low socioeconomic status had a 2.2-fold increased risk of developing intestinal type gastric cancer. Those who had nine years or less of education had a 1.9-fold increased risk of developing this type of cancer. Also, immigrants born in Asian and former USSR countries had higher risks of developing gastric cancer (3.0-fold and 2.28-fold increased risks, respectively).
“Adolescents who are overweight and obese are prone to esophageal cancer, probably due to reflux that they have throughout their life. Also, a lower socioeconomic position as a child has a lot of impact upon incidence of gastric cancer as an adult,” said Dr. Levi. “We look at obesity as dangerous from cardiovascular aspects at ages 40 and over, but here we can see that it has effects much earlier.” He noted that it is unclear whether losing weight later in life or gaining higher socioeconomic status might reduce the risks observed in this study.
