生物谷報道：本期Nature上報道了華人科學家施一公（著名的結構生物學家）發(fā)現(xiàn)了線蟲中兩種蛋白CED-4和CED-9（與高等生物中的caspase家族一致）相互作用的結構學基礎，從而從結構學水平上揭示了它們共同導致細胞凋亡的機制。
這篇文章突破了兩種蛋白質相互作用的結構學基礎的研究,，從而從結構上揭示蛋白質間相互作用。
a, The CED-4a−CED-4b interactions consist of a primary (orange circle) and a secondary (magenta circle) site. b, A stereo view of the primary interface of the CED-4 dimer. Helices 8, 11 and 11b, from CED-4b, stack against the CARD and / domains of CED-4a. c, ATP and magnesium are buried in CED-4. ATP molecules and magnesium ions are highlighted in yellow and magenta, respectively. d, A stereo view of ATP coordination in CED-4. Hydrogen bonds are represented by red dashed lines. ATP is shown in orange, with nitrogen and oxygen atoms shown in blue and red, respectively.
原文來源：
Nieng Yan, Jijie Chai, Eui Seung Lee, Lichuan Gu, Qun Liu, Jiaqing He, Jia-Wei Wu, David Kokel, Huilin Li, Quan Hao, Ding Xue and Yigong Shi. Structure of the CED-4−CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans, Nature 437, 831-837 (6 October 2005)
