生物谷報道：生命體系中諸多基本結(jié)構(gòu)單元在特定的環(huán)境下,，能自發(fā)地進行自組裝,，形成各種各樣的納米結(jié)構(gòu),。肽基的自組裝體系可以作為組織修復(fù)的骨架,，用于生物工程界面和跨膜離子通道的研究,，其在藥物,、蛋白和基因的傳輸方面有很好的應(yīng)用前景,。
在中國科學(xué)院和國家自然科學(xué)基金委的支持下，膠體,、界面與化學(xué)熱力學(xué)院重點實驗室的研究人員在仿生體系的分子組裝方面取得新進展,，相關(guān)研究工作發(fā)表在近期的Angew. Chem. Int. Ed. (2007, 46, 2431-2434)上。
前期工作中,，該研究組利用“微乳法”和“層層組裝技術(shù)”在仿生膜的分子組裝方面取得系列進展(Angew. Chem. Int. Ed. 2001, 40 , 891,；ChemBioChem., 2003, 4, 299； ChemPhysChem, 2003, 4, 1355,；J. Phys. Chem. B, 2004, 108, 473),。用分子組裝的方法和概念，在流體表面或生物基質(zhì)中,，進行仿生物膜結(jié)構(gòu)的有序組裝,，通過對組裝膜的結(jié)構(gòu)與功能進行調(diào)控,，使組裝體系在某種程度上具有生物膜的功能。
在以上工作基礎(chǔ)上,，研究人員發(fā)現(xiàn)陽離子二肽在中性條件下可以自組裝成納米管,，通過改變自組裝體系的濃度，納米管能進一步轉(zhuǎn)化為囊泡,，利用此轉(zhuǎn)變過程可將寡核苷酸(ss-DNA)通過細(xì)胞的吞噬作用攜入細(xì)胞內(nèi),，從而實現(xiàn)外緣物質(zhì)的胞內(nèi)輸送。該研究工作為肽基生物材料在藥物傳輸方面的應(yīng)用提供了實驗基礎(chǔ),。（引自化學(xué)研究所）
原始出處:
Angewandte Chemie International Edition , Volume 46, Issue 14 , Pages 2431 - 2434
Published Online: 28 Feb 2007
Transition of Cationic Dipeptide Nanotubes into Vesicles and Oligonucleotide Delivery
Xuehai Yan 1, Qiang He, Dr. 1 2, Kewei Wang 1, Li Duan 1, Yue Cui, Dr. 1, Junbai Li, Prof. Dr. 1 *
1Beijing National Laboratory for Molecular Sciences (BNLMS), International Joint Laboratory, Key Laboratory of Colloid and Interface Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, P. R. China, Fax: (+86) 10-8261-2629
2Max Planck Institute of Colloids and Interfaces, 14476 Golm/Potsdam, Germany
email: Junbai Li ([email protected])
*Correspondence to Junbai Li, 1Beijing National Laboratory for Molecular Sciences (BNLMS), International Joint Laboratory, Key Laboratory of Colloid and Interface Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, P. R. China, Fax: (+86) 10-8261-2629
Communication
Transition of Cationic Dipeptide Nanotubes into Vesicles and Oligonucleotide Delivery
Xuehai Yan 1, Qiang He, Dr. 1 2, Kewei Wang 1, Li Duan 1, Yue Cui, Dr. 1, Junbai Li, Prof. Dr. 1 *
1Beijing National Laboratory for Molecular Sciences (BNLMS), International Joint Laboratory, Key Laboratory of Colloid and Interface Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, P. R. China, Fax: (+86) 10-8261-2629
2Max Planck Institute of Colloids and Interfaces, 14476 Golm/Potsdam, Germany
email: Junbai Li ([email protected])
*Correspondence to Junbai Li, 1Beijing National Laboratory for Molecular Sciences (BNLMS), International Joint Laboratory, Key Laboratory of Colloid and Interface Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, P. R. China, Fax: (+86) 10-8261-2629
This work was supported financially by the National Natural Science Foundation of China (Nos. 20574077, 20471063, 20403022, and 90206035) and the Chinese Academy of Sciences, as well as the German Max Planck Society collaboration project. The authors acknowledge Hans Riegler for critical reading of the manuscript.
Funded by:
National Natural Science Foundation of China; Grant Number: 20574077, 20471063, 20403022, 90206035
Chinese Academy of Sciences
Max Planck Society
Keywords
cells ?oligonucleotides ?peptide nanotubes ?self-assembly ?vesicles
