赤霉素是一種重要的植物激素,，調(diào)控幾個(gè)發(fā)育過(guò)程,。赤霉素與其受體GID1的結(jié)合,，導(dǎo)致DELLA家族的轉(zhuǎn)錄調(diào)控因子的識(shí)別,，這些調(diào)控因子抑制赤霉素信號(hào)作用,。
現(xiàn)在，兩個(gè)小組發(fā)表了來(lái)自兩種不同植物物種的赤霉素受體的晶體結(jié)構(gòu),。Murase等人確定了與GID1和來(lái)自擬南芥的一個(gè)DELLA蛋白碎片相結(jié)合的赤霉素的一種三元復(fù)合物的結(jié)構(gòu),。Shimada等人對(duì)與水稻GID1相結(jié)合的赤霉素進(jìn)行了研究。這些結(jié)構(gòu)揭示了一個(gè)受體識(shí)別機(jī)制,，該機(jī)制與生長(zhǎng)素的識(shí)別機(jī)制截然不同,。關(guān)于受體結(jié)構(gòu)的詳細(xì)知識(shí)，有可能幫助設(shè)計(jì)用于農(nóng)業(yè)生產(chǎn)的更為有效或更為便宜的生長(zhǎng)調(diào)控因子,。（生物谷Bioon.com）
生物谷推薦原始出處：
Nature 456, 459-463 (27 November 2008) | doi:10.1038/nature07519
Gibberellin-induced DELLA recognition by the gibberellin receptor GID1
Kohji Murase1,2,3, Yoshinori Hirano1,3, Tai-ping Sun2 & Toshio Hakoshima1
1 Structural Biology Laboratory, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan
2 Department of Biology, Duke University, Durham, North Carolina 27708, USA
3 These authors contributed equally to this work.
Gibberellins control a range of growth and developmental processes in higher plants and have been widely used in the agricultural industry. By binding to a nuclear receptor, GIBBERELLIN INSENSITIVE DWARF1 (GID1), gibberellins regulate gene expression by promoting degradation of the transcriptional regulator DELLA proteins, including GIBBERELLIN INSENSITIVE (GAI). The precise manner in which GID1 discriminates and becomes activated by bioactive gibberellins for specific binding to DELLA proteins remains unclear. Here we present the crystal structure of a ternary complex of Arabidopsis thaliana GID1A, a bioactive gibberellin and the amino-terminal DELLA domain of GAI. In this complex, GID1A occludes gibberellin in a deep binding pocket covered by its N-terminal helical switch region, which in turn interacts with the DELLA domain containing DELLA, VHYNP and LExLE motifs. Our results establish a structural model of a plant hormone receptor that is distinct from the mechanism of the hormone perception and effector recognition of the known auxin receptors.
