結(jié)構(gòu)生物學(xué)國際著名專家施一公回國后在清華大學(xué)建立了自己的實驗室,，近期,，他在新的實驗室以清華的名義發(fā)表的文章2008年12月14日在線刊登在Nature子刊：Nature Structure & Molecular biologyonline上，文章題為：“Crystal structure of TIPE2 provides insight into Immune homeostasis,。”
TNFAIP8-like 2（TIPE2）在維持免疫內(nèi)環(huán)境的過程具有重要的意義,，但是關(guān)于TIPE2的工作機制至今不明晰。清華大學(xué)施一公的研究小組對TIPE2的晶體結(jié)構(gòu)進行了分析,，發(fā)現(xiàn)其真實的蛋白折疊結(jié)構(gòu)與先前用軟件預(yù)測的折疊結(jié)構(gòu)有出入,，尤其是該蛋白的死亡效應(yīng)區(qū)域（death effector domain）結(jié)構(gòu)。明顯的,，TIPE2蛋白具有一個巨大的疏水中央腔體結(jié)構(gòu),，該區(qū)域具有協(xié)助蛋白結(jié)合的功能。探明TIPE2蛋白的結(jié)構(gòu)的意義在于深入了解TIPE2蛋白的功能和作用機制,，并且對TNFAIP8蛋白家族的結(jié)構(gòu)預(yù)測也具有借鑒指導(dǎo)意義,。（生物谷Bioon.com）
生物谷推薦原始出處：
Nature Structural & Molecular Biology 16, 89 - 90 (2008) Published online: 14 December 2008 | doi:10.1038/nsmb.1522
Crystal structure of TIPE2 provides insights into immune homeostasis
Xu Zhang1, Jiawei Wang1, Chao Fan1, Hubo Li1, Honghong Sun2, Shunyou Gong2, Youhai H Chen2 & Yigong Shi1,3
TNFAIP8-like 2 (TIPE2) has an essential role in immune homeostasis, yet the underlying mechanism remains enigmatic. The high-resolution crystal structure of TIPE2 reveals a previously uncharacterized fold that is different from the predicted fold of a death effector domain (DED). Strikingly, TIPE2 contains a large, hydrophobic central cavity that is poised for cofactor binding. These structural features will be important for understanding the functions of TIPE2 and other TNFAIP8 family proteins.
1 Center for Structural Biology and Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.
2 Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
3 Tsinghua University School of Medicine, Beijing 100084, China.
