2012年5月24日,，Structure在線發(fā)表了新加坡分子與細(xì)胞生物學(xué)研究所洪萬(wàn)進(jìn)課題組等的一篇題為Structural and Functional Similarity between the Vgll1-TEAD and the YAP-TEAD Complexes的研究論文,，報(bào)道了Vgll1-TEAD4復(fù)合體的三維晶體,，并與YAP/TAZ-TEAD復(fù)合體進(jìn)行比較，發(fā)現(xiàn)兩者結(jié)構(gòu)與功能的相似性,。
通過(guò)Vgll1-TEAD與YAP-TEAD復(fù)合體比較發(fā)現(xiàn),，兩者結(jié)構(gòu)高度相似。
進(jìn)一步研究發(fā)現(xiàn),，兩者的功能也基本一致,。他們都具有上調(diào)細(xì)胞增殖促進(jìn)基因( proliferation-promoting gene ) 的表達(dá)和促進(jìn)錨定依賴細(xì)胞（anchorage-independent cell）增殖的作用,。
鑒于Vgll1與YAP/TAZ結(jié)構(gòu)和功能上的相似性，Vgll1也可能具有促使癌細(xì)胞增殖的能力,。(生物谷Bioon.com)
doi:10.1016/j.str.2012.04.004
PMC:
PMID:
Structural and Functional Similarity between the Vgll1-TEAD and the YAP-TEAD Complexes
Ajaybabu V. Pobbati,， Siew Wee Chan， Ian Lee,， Haiwei Song,， Wanjin HongSee Affiliations
Hint： Rollover Authors and Affiliations
Cell Biology in Health and Disease Division， Institute of Molecular and Cell Biology,， Proteos,， Singapore 138673
Structural Biology and Drug Discovery， Institute of Molecular and Cell Biology,， Proteos,， Singapore 138673
Genome Institute of Singapore， Genome,， Singapore 138672
Department of Biochemistry,， National University of Singapore， Singapore 117543
Highlights
Vgll1-TEAD complex is structurally similar to the YAP-TEAD complex
Structural similarity is striking as Vgll1 and YAP have a different primary sequence
These complexes upregulate proliferation-promoting genes
They also induce anchorage-independent cell proliferation
Summary
The structure of the complex between the transcription cofactor Vgll1 and the transcription factor TEAD4,， the mammalian equivalent of the Drosophila Vestigial and Scalloped,， respectively， is determined in this study. Remarkably,， Vgll1 interacts with TEAD in a manner similar to the transcription coactivators,， as well as oncogenes YAP and TAZ， despite having a varied primary sequence. Vgll1-TEAD complex upregulates the expression of IGFBP-5,， a proliferation-promoting gene,， and facilitates anchorage-independent cell proliferation. The YAP/TAZ-TEAD complex also upregulates several other proliferation-promoting genes and also promotes anchorage-independent cell proliferation. Given its structural and functional similarity to YAP/TAZ， Vgll1 has the potential to promote cancer progression.
