生物谷按：功能基因組和功能蛋白質(zhì)組學(xué)的研究為人類揭示生命活動(dòng)的本質(zhì)提供了強(qiáng)有力的工具,，然而我們也應(yīng)看到當(dāng)前的研究還存在很大的局限性,，如何通過這些復(fù)雜數(shù)據(jù)，采用何種有效的分析策略揭示生物活動(dòng)的本質(zhì)特征,，揭示細(xì)胞活動(dòng)網(wǎng)絡(luò)的動(dòng)力學(xué)特征,，是未來二十年內(nèi)科學(xué)家思考最多的問題之一。如細(xì)胞信號轉(zhuǎn)導(dǎo)根本不是我們現(xiàn)階段認(rèn)識的單一途徑和模式,，也不是線性化的,，而是一個(gè)復(fù)雜調(diào)控的網(wǎng)絡(luò)體系，這個(gè)網(wǎng)絡(luò)體系是一個(gè)復(fù)雜的動(dòng)態(tài)平衡系統(tǒng),，它能將外界的信息快速有效傳遞到細(xì)胞內(nèi),，然后對該信號產(chǎn)生應(yīng)激，同時(shí)這個(gè)系統(tǒng)會將該刺激信息作為一個(gè)信息會記憶和儲存在這個(gè)系統(tǒng)中,。這篇文章提出了初步的看法,。
From functional genomics to systems biology: concepts and practices.
Auffray C, Imbeaud S, Roux-Rouquie M, Hood L.
C R Biol. 2003 Oct-Nov;326(10-11):879-92.
Genexpress, Functional Genomics and Systemic Biology for Health, CNRS FRE 2571, 7, rue Guy-Moquet, BP 8, 94801 Villejuif cedex, France. [email protected]
Systems biology is the iterative and integrative study of biological systems as systems in response to perturbations. It is founded on hypotheses formalized in models built from the results of global functional genomics analyses of the complexity of the genome, transcriptome, proteome, metabolome, etc. Its implementation by cross-disciplinary teams in a standardized mode under quality assurance should allow accessing the small variations of the large number of elements determining functioning of biological systems. Galactose utilization in yeast, and sea urchin development are two examples of emerging systems biology.
