生物谷報道：心血管疾病是當(dāng)今社會人類主要?dú)⑹种弧：芏嗳硕贾溃３忠粋€好的生活習(xí)慣，比如恰當(dāng)飲食,、足夠鍛煉以及戒煙等，可以幫助預(yù)防心血管疾病,。美國科學(xué)家近日稱,，每天兩次使用牙刷和牙線清潔牙齒，或許也可達(dá)到相同的效果,。因?yàn)樗麄冄芯堪l(fā)現(xiàn),，牙周病患者心血管疾病患病風(fēng)險比普通人高。相關(guān)論文發(fā)表在2007年12月份的《牙周病學(xué)雜志》（Journal of Periodontology）上,。
最新研究由美國霍華德大學(xué)的Indra Z. Mustapha領(lǐng)導(dǎo)完成,。研究人員重新分析了11例牙周病與心血管疾病相關(guān)性的研究，測量了參與者身體內(nèi)細(xì)菌水平,，特別是與牙周病有關(guān)的細(xì)菌,，并測量了多種生物指示劑的水平。結(jié)果發(fā)現(xiàn),，患有牙周病的個體更易患冠心病和動脈粥樣化形成,。
《牙周病學(xué)雜志》編輯Kenneth Kornman表示，“之前有很多研究發(fā)現(xiàn),，口腔疾病與心臟病之間可能存在聯(lián)系,，但是對于其中的原因以及發(fā)生的條件卻不得而知。此次研究表明,，慢性牙周炎的長期作用最終可能會導(dǎo)致心血管疾病,。”
美國牙周病學(xué)會（AAP）會長Susan Karabin說：“雖然還需要更多的研究以更好了解牙周病和心血管疾病之間的關(guān)系，但此次研究表明了保護(hù)牙齒和口腔的重要性,，這樣能夠保護(hù)我們的心臟,。隨著心臟病患者的增加，如下這些事情是很重要的,，即一天兩次使用牙刷和牙線清潔牙齒,，定期去看牙醫(yī),，這樣將能夠幫助降低導(dǎo)致其它健康問題的風(fēng)險,。”（生物谷援引科學(xué)網(wǎng)）
生物谷推薦英文原文：
Abstract
Journal of Periodontology
2007, Vol. 78, No. 12, Pages 2289-2302
(doi:10.1902/jop.2007.070140)
Markers of Systemic Bacterial Exposure in Periodontal Disease and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis
Indra Z. Mustapha,* Sarah Debrey, Michael Oladubu, and Richard Ugarte§
*Department of Periodontology, Howard University, Washington, DC.
†Stroke Neuroscience Unit, National Institutes of Health, Bethesda, MD.
‡Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
§Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD.
Correspondence: Dr. Indra Z. Mustapha, 701 Pennsylvania Ave. NW, #1028, Washington, DC 20004. E-mail: [email protected].
Background: Recent meta-analyses reported a weak association between periodontal disease (PD) on clinical examination and cardiovascular disease (CVD). Systemic bacterial exposure from periodontitis, which correlates poorly with the clinical examination, has been proposed as the more biologically pertinent risk factor. The purpose of this study was to review and analyze the association between PD with elevated systemic bacterial exposure and CVD.
Methods: We searched in the PubMed, Cochrane Controlled Trials Register, EMBASE, and SCOPUS databases for all literature examining PD and CVD. From 10 selected publications, we extracted 12 cohort (N = 5) and cross-sectional (N = 7) studies and included 11 of these in a meta-analysis. With stratified analyses, this resulted in 14 analyses of coronary heart disease (CHD; N = 7), stroke (N = 4), and carotid intima-medial thickening (CIMT; N = 3) as a measure of early atherosclerosis. Systemic bacterial exposure was measured by periodontal bacterial burden (N = 1), periodontitis-specific serology (N = 12), or C-reactive protein (N = 1).
Results: Periodontal disease with elevated markers of systemic bacterial exposure was associated strongly with CHD compared to subjects without PD, with a summary odds ratio of 1.75 (95% confidence interval (CI): 1.32 to 2.34; P <0.001). This group was not associated with CVD events or with stroke but was associated with a significant increase in mean CIMT (0.03 mm; 95% CI: 0.02 to 0.04).
Conclusion: Periodontal disease with elevated bacterial exposure is associated with CHD events and early atherogenesis (CIMT), suggesting that the level of systemic bacterial exposure from periodontitis is the biologically pertinent exposure with regard to atherosclerotic risk.
KEYWORDS: Cardiovascular disease, C-reactive protein, immunoglobulins, periodontal disease, periodontitis, stroke
