2012年9月23日 訊 /生物谷BIOON/ --近日,，哈佛大學(xué)公共衛(wèi)生學(xué)院的研究者發(fā)現(xiàn)大量飲用含糖飲料（SSBs,，sugar-sweetened beverages）可增加高身體質(zhì)量指數(shù)（BMI,，body mass index）的遺傳易感性，增加肥胖風(fēng)險,。相關(guān)論文發(fā)表在9月21日的New England Journal of Medicine上,。
在過去的30年,，含糖飲料的消耗在全球范圍內(nèi)都有顯著增長。盡管大量證據(jù)表明含糖飲料與肥胖及糖尿病等代謝疾病都有關(guān),，卻沒有環(huán)境因素如含糖飲料是否影響肥胖遺傳易感性的研究,。
這項(xiàng)研究共包括三個部分--121,700個女性參與的Nurses' Health Study，51,529個男性參與的Health Professionals Follow-up Study和25,000個女性參與的Women's Genome Health Study,。在此研究過程中,，所有的參與者都要填寫他們食物和飲料消耗情況的詳細(xì)表格。
研究者對有歐洲血統(tǒng)的參與者進(jìn)行了全基因組關(guān)聯(lián)分析,。根據(jù)含糖飲料消耗的量,，這些參與者被分成四組：每月少于一份、每月1-4份,、每周2-6份,、每天一份或多于一份。為將遺傳易感性量化,，以32個已知與BMI相關(guān)的單核苷酸多態(tài)性為基礎(chǔ)進(jìn)行打分,。
結(jié)果顯示，每天飲用一份或更多的含糖飲料所引發(fā)的肥胖風(fēng)險是每月不喝含糖飲料的兩倍,，表明經(jīng)常飲用含糖飲料可能增加肥胖的遺傳風(fēng)險,。此外，對肥胖有遺傳易感性的人受含糖飲料的影響更大,。
因此,，遺傳和飲食因素--含糖飲料可以相互影響彼此對體重和肥胖的作用。含糖飲料是肥胖流行的因素之一,，這項(xiàng)研究給我們的啟示是,，肥胖的遺傳效應(yīng)可以被健康的飲食和飲料抵消。（生物谷Bioon.com）
編譯自Regular consumption of sugary beverages linked to increased genetic risk of obesity
doi: 10.1056/NEJMoa1203039
PMC:
PMID:
Sugar-Sweetened Beverages and Genetic Risk of Obesity
Qibin Qi, Ph.D., Audrey Y. Chu, Ph.D., Jae H. Kang, Sc.D., Majken K. Jensen, Ph.D., Gary C. Curhan, M.D., Sc.D., Louis R. Pasquale, M.D., Paul M. Ridker, M.D., M.P.H., David J. Hunter, M.B., B.S., Sc.D., Walter C. Willett, M.D., Dr.P.H., Eric B. Rimm, Sc.D., Daniel I. Chasman, Ph.D., Frank B. Hu, M.D., Ph.D., and Lu Qi, M.D., Ph.D.
Background
Temporal increases in the consumption of sugar-sweetened beverages have paralleled the rise in obesity prevalence, but whether the intake of such beverages interacts with the genetic predisposition to adiposity is unknown.
Methods
We analyzed the interaction between genetic predisposition and the intake of sugar-sweetened beverages in relation to body-mass index (BMI; the weight in kilograms divided by the square of the height in meters) and obesity risk in 6934 women from the Nurses' Health Study (NHS) and in 4423 men from the Health Professionals Follow-up Study (HPFS) and also in a replication cohort of 21,740 women from the Women's Genome Health Study (WGHS). The genetic-predisposition score was calculated on the basis of 32 BMI-associated loci. The intake of sugar-sweetened beverages was examined prospectively in relation to BMI.
Results
In the NHS and HPFS cohorts, the genetic association with BMI was stronger among participants with higher intake of sugar-sweetened beverages than among those with lower intake. In the combined cohorts, the increases in BMI per increment of 10 risk alleles were 1.00 for an intake of less than one serving per month, 1.12 for one to four servings per month, 1.38 for two to six servings per week, and 1.78 for one or more servings per day (P<0.001 for interaction). For the same categories of intake, the relative risks of incident obesity per increment of 10 risk alleles were 1.19 (95% confidence interval [CI], 0.90 to 1.59), 1.67 (95% CI, 1.28 to 2.16), 1.58 (95% CI, 1.01 to 2.47), and 5.06 (95% CI, 1.66 to 15.5) (P=0.02 for interaction). In the WGHS cohort, the increases in BMI per increment of 10 risk alleles were 1.39, 1.64, 1.90, and 2.53 across the four categories of intake (P=0.001 for interaction); the relative risks for incident obesity were 1.40 (95% CI, 1.19 to 1.64), 1.50 (95% CI, 1.16 to 1.93), 1.54 (95% CI, 1.21 to 1.94), and 3.16 (95% CI, 2.03 to 4.92), respectively (P=0.007 for interaction).
