六種假絲酵母（Candida）的基因組序列已被確定，并與白念珠菌（一種海洋酵母和面包酵母）的基因組序列進(jìn)行了對(duì)比,。假絲酵母是人類所遭受的伺機(jī)性真菌感染的最常見原因,。
基因組對(duì)比顯示了與致病性物種相關(guān)的驚人的基因家族擴(kuò)展現(xiàn)象。假絲酵母生物學(xué)的其他方面,，包括遺傳編碼的演化,，以及交配和減數(shù)分裂過程的架構(gòu)，也可通過對(duì)不同物種進(jìn)行對(duì)比來研究,。(生物谷Bioon.com)
生物谷推薦原始出處：
Nature 459, 657-662 (4 June 2009) | doi:10.1038/nature08064
Evolution of pathogenicity and sexual reproduction in eight Candida genomes
Geraldine Butler1, Matthew D. Rasmussen2, Michael F. Lin2,3, Manuel A. S. Santos4, Sharadha Sakthikumar3, Carol A. Munro5, Esther Rheinbay2,6, Manfred Grabherr3, Anja Forche7, Jennifer L. Reedy8, Ino Agrafioti9, Martha B. Arnaud10, Steven Bates11, Alistair J. P. Brown5, Sascha Brunke12, Maria C. Costanzo10, David A. Fitzpatrick1, Piet W. J. de Groot13, David Harris14, Lois L. Hoyer15, Bernhard Hube12, Frans M. Klis13, Chinnappa Kodira3,22, Nicola Lennard14, Mary E. Logue1, Ronny Martin12, Aaron M. Neiman16, Elissavet Nikolaou5, Michael A. Quail14, Janet Quinn17, Maria C. Santos4, Florian F. Schmitzberger10, Gavin Sherlock10, Prachi Shah10, Kevin A. T. Silverstein18, Marek S. Skrzypek10, David Soll19, Rodney Staggs18, Ian Stansfield5, Michael P. H. Stumpf9, Peter E. Sudbery20, Thyagarajan Srikantha19, Qiandong Zeng3, Judith Berman7, Matthew Berriman14, Joseph Heitman8, Neil A. R. Gow5, Michael C. Lorenz21, Bruce W. Birren3, Manolis Kellis2,3,23 & Christina A. Cuomo3,23
Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.
