一個國際科研團隊7日發(fā)布報告稱，他們已經(jīng)對家養(yǎng)火雞的基因組90%以上的區(qū)域完成測序,。
研究人員表示,，短期內(nèi)，測序結(jié)果就可以提供對火雞產(chǎn)量,、質(zhì)量,、發(fā)育、生殖以及抗病至關(guān)重要的基因的信息,，科學家可以據(jù)此培育出肥瘦,、口感不同的火雞品種，提高火雞疾病預防和治療手段,。
這項測序的大部分數(shù)據(jù)來自火雞的10個最大的染色體,。研究人員表示，通過這項始于2008年的項目,，他們已經(jīng)發(fā)現(xiàn)了數(shù)千個此前不為鳥類科學家所知的基因,，此前研究甚少的火雞性染色體的測序結(jié)果也令人感興趣。
來自澳大利亞,、英國,、德國、荷蘭,、韓國,、西班牙以及美國的研究人員參與了火雞基因組測序工作。相關(guān)研究成果下周將發(fā)表在美國《公共科學圖書館·生物學》雜志網(wǎng)絡(luò)版上,。（生物谷Bioon.com）
生物谷推薦英文摘要：
PLoS Biology 8(9): e1000475. doi:10.1371/journal.pbio.1000475
Multi-Platform Next-Generation Sequencing of the Domestic Turkey (Meleagris gallopavo): Genome Assembly and Analysis
A synergistic combination of two next-generation sequencing platforms with a detailed comparative BAC physical contig map provided a cost-effective assembly of the genome sequence of the domestic turkey (Meleagris gallopavo). Heterozygosity of the sequenced source genome allowed discovery of more than 600,000 high quality single nucleotide variants. Despite this heterozygosity, the current genome assembly (~1.1 Gb) includes 917 Mb of sequence assigned to specific turkey chromosomes. Annotation identified nearly 16,000 genes, with 15,093 recognized as protein coding and 611 as non-coding RNA genes. Comparative analysis of the turkey, chicken, and zebra finch genomes, and comparing avian to mammalian species, supports the characteristic stability of avian genomes and identifies genes unique to the avian lineage. Clear differences are seen in number and variety of genes of the avian immune system where expansions and novel genes are less frequent than examples of gene loss. The turkey genome sequence provides resources to further understand the evolution of vertebrate genomes and genetic variation underlying economically important quantitative traits in poultry. This integrated approach may be a model for providing both gene and chromosome level assemblies of other species with agricultural, ecological, and evolutionary interest.
Rami A. Dalloul1#, Julie A. Long2#, Aleksey V. Zimin3#, Luqman Aslam4, Kathryn Beal5, Le Ann Blomberg2, Pascal Bouffard6, David W. Burt7, Oswald Crasta8,9, Richard P. M. A. Crooijmans4, Kristal Cooper8, Roger A. Coulombe10, Supriyo De11, Mary E. Delany12, Jerry B. Dodgson13, Jennifer J. Dong14, Clive Evans8, Karin M. Frederickson6, Paul Flicek5, Liliana Florea15, Otto Folkerts8,9, Martien A. M. Groenen4, Tim T. Harkins6, Javier Herrero5, Steve Hoffmann16,17, Hendrik-Jan Megens4, Andrew Jiang12, Pieter de Jong18, Pete Kaiser19, Heebal Kim20, Kyu-Won Kim20, Sungwon Kim1, David Langenberger16, Mi-Kyung Lee14, Taeheon Lee20, Shrinivasrao Mane8, Guillaume Marcais3, Manja Marz16,21, Audrey P. McElroy1, Thero Modise8, Mikhail Nefedov18, Cédric Notredame22, Ian R. Paton7, William S. Payne13, Geo Pertea15, Dennis Prickett19, Daniela Puiu15, Dan Qioa23, Emanuele Raineri22, Magali Ruffier24, Steven L. Salzberg25, Michael C. Schatz25, Chantel Scheuring14, Carl J. Schmidt26, Steven Schroeder27, Stephen M. J. Searle24, Edward J. Smith1, Jacqueline Smith7, Tad S. Sonstegard27, Peter F. Stadler16,28,29,30,31, Hakim Tafer16,30, Zhijian (Jake) Tu32, Curtis P. Van Tassell27,33, Albert J. Vilella5, Kelly P. Williams8, James A. Yorke3, Liqing Zhang23, Hong-Bin Zhang14, Xiaojun Zhang14, Yang Zhang14, Kent M. Reed34*
