近日英國科學(xué)家發(fā)現(xiàn)導(dǎo)致肥胖的基因。科學(xué)家們認(rèn)為該基因在人體脂肪細(xì)胞內(nèi)控制著其他基因，它的發(fā)現(xiàn)對于幫助治療像心臟病、糖尿病等肥胖相關(guān)疾病是個(gè)突破,。
科學(xué)家從800名女性或雙胞胎體內(nèi)提取肥胖細(xì)胞，并研究了肥胖細(xì)胞中的2萬個(gè)基因,。
科學(xué)家還找到一種名為KLF14的基因,，這種基因被認(rèn)為與二型糖尿病和膽固醇值有關(guān)。
科學(xué)家在《自然遺傳學(xué)》雜志上發(fā)表了研究結(jié)果,，該結(jié)果表明脂肪對導(dǎo)致如肥胖,、心臟病和糖尿病等代謝性疾病起著很重要的作用。
醫(yī)生稱可以根據(jù)這個(gè)發(fā)現(xiàn)找到針對這種基因的藥物,。（生物谷Bioon.com）
生物谷推薦原文：
Nature Genetics DOI:10.1038/ng.833
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes
Kerrin S Small,Elin Grundberg,Alexandra C Nica, Gudmar Thorleifsson, Augustine Kong, Unnur Thorsteindottir, So-Youn Shin, Hannah B Richards
Genome-wide association studies have identified many genetic variants associated with complex traits. However, at only a minority of loci have the molecular mechanisms mediating these associations been characterized. In parallel, whereas cis regulatory patterns of gene expression have been extensively explored, the identification of trans regulatory effects in humans has attracted less attention. Here we show that the type 2 diabetes and high-density lipoprotein cholesterol–associated cis-acting expression quantitative trait locus (eQTL) of the maternally expressed transcription factor KLF14 acts as a master trans regulator of adipose gene expression. Expression levels of genes regulated by this trans-eQTL are highly correlated with concurrently measured metabolic traits, and a subset of the trans-regulated genes harbor variants directly associated with metabolic phenotypes. This trans-eQTL network provides a mechanistic understanding of the effect of the KLF14 locus on metabolic disease risk and offers a potential model for other complex traits.
