據(jù)日本共同社5月16日消息,，日本國(guó)立國(guó)際醫(yī)療研究中心研究所（位于東京）等組成的國(guó)際研究小組5月16日在英國(guó)科學(xué)雜志《自然—遺傳學(xué)》（Nature Genetics）電子版上發(fā)表論文稱,，解析中日韓等約5萬(wàn)東亞人的基因組（genome）后,，發(fā)現(xiàn)了13處與高血壓有關(guān)的基因,。
該研究所表示,，此前已有以歐美人為對(duì)象的報(bào)告,，但以東亞人為對(duì)象尚屬首次,。據(jù)悉,，本次研究發(fā)現(xiàn)的基因有些與歐美人不同,，或?qū)⒂欣诎l(fā)展適應(yīng)不同人種的新型治療、預(yù)防和診斷方法,。
研究小組首先對(duì)約2萬(wàn)東亞人的基因組展開調(diào)查,，發(fā)現(xiàn)了約240處可能與高血壓有關(guān)的基因。然后又對(duì)另外的約1萬(wàn)人進(jìn)行調(diào)查，將范圍縮小為關(guān)聯(lián)性較強(qiáng)之處,。最后,，通過(guò)對(duì)另外的2萬(wàn)余人的分析，最終進(jìn)行了確認(rèn),。
研究結(jié)果顯示共有13處與高血壓相關(guān),，其中6處為此次首次發(fā)現(xiàn)。另外,，13處基因中有些還與酒精分解相關(guān),。
該研究所基因診斷治療開發(fā)研究部部長(zhǎng)加藤規(guī)弘表示：“東亞人的基因組具有特殊之處，這可能是為了適應(yīng)某種環(huán)境的結(jié)果,。”（生物谷Bioon.com）
生物谷推薦原文出處：
Nature Genetics DOI:10.1038/ng.834
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians
Norihiro Kato; Fumihiko Takeuchi; Yasuharu Tabara; Tanika N Kelly; Min Jin Go; Xueling Sim; Wan Ting Tay; Chien-Hsiun Chen; Yi Zhang; Ken Yamamoto; Tomohiro Katsuya; Mitsuhiro Yokota; Young Jin Kim; Rick Twee Hee Ong; Toru Nabika; Dongfeng Gu; Li-ching Chang; Yoshihiro Kokubo; Wei Huang; Keizo Ohnaka; Yukio Yamori; Eitaro Nakashima; Cashell E Jaquish; Jong-Young Lee; Mark Seielstad; Masato Isono; James E Hixson; Yuan-Tsong Chen; Tetsuro Miki; Xueya Zhou; Takao Sugiyama; Jae-Pil Jeon; Jian Jun Li
We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP consortium followed up with de novo genotyping (n = 10,518) and further replication (n = 20,247) in east Asian samples. We identified genome-wide significant (P < 5 × 10?8) associations with SBP or DBP, which included variants at four new loci (ST7L-CAPZA1, FIGN-GRB14, ENPEP and NPR3) and a newly discovered variant near TBX3. Among the five newly discovered variants, we obtained significant replication in the independent samples for all of these loci except NPR3. We also confirmed seven loci previously identified in populations of European descent. Moreover, at 12q24.13 near ALDH2, we observed strong association signals (P = 7.9 × 10?31 and P = 1.3 × 10?35 for SBP and DBP, respectively) with ethnic specificity. These findings provide new insights into blood pressure regulation and potential targets for intervention.
