動脈粥樣硬化是已被公認(rèn)的腦卒中獨立危險因素之一,，其發(fā)生與血脂代謝有著極為密切的聯(lián)系,。人們推測高水平的B族I型清道夫受體在介導(dǎo)高密度脂蛋白的抗動脈粥樣硬化發(fā)生方面可能具有很重要的作用。目前已有的對B族I型清道夫受體基因多態(tài)性的研究主要是針對外顯子1 G4A多態(tài)和外顯子8 C1050T多態(tài),，其中外顯子1 G4A多態(tài)對血脂的影響獲得較多的支持,，該多態(tài)位點不僅對部分人種健康人群血脂有一定的影響,，還參與了糖尿病患者血脂代謝紊亂,?！吨袊窠?jīng)再生研究（英文版）》雜志2013年6月第16期發(fā)表的一項關(guān)于“Susceptibility gene for stroke or cerebral infarction in the Han population in Hunan Province of China”的研究證實，動脈粥樣硬化性腦梗死患者外周血B族I型清道夫受體基因外顯子1 G4A的A等位基因頻率明顯低于正常對照者,。但B族I型清道夫受體外顯子1 G4A GA＋AA基因型的動脈粥樣硬化性腦梗死和腦出血患者外周血高密度脂蛋白膽固醇水平均顯著高于GG基因型患者,，而低密度脂蛋白膽固醇水平均顯著低于GG基因型患者。作為認(rèn)為,，B族I型清道夫受體基因外顯子1 G4A多態(tài)性可能與中國湖南地區(qū)漢族人群腦出血無關(guān),，而與動脈粥樣硬化性腦梗死有關(guān)，且A等位基因可能與高密度脂蛋白和低密度脂蛋白代謝有關(guān),。（生物谷 Bioon.com）

生物谷推薦的英文摘要

Neural Regeneration Research Doi:10.3969/j.issn.1673-5374.2013.16.009

Susceptibility gene for stroke or cerebral infarctionin the Han population in Hunan Province of China

Danheng Mo, Hongwei Xu, Wensheng Zhou, Qiming Yang, Jianwen Yang, Bo Xiao, Qidong Yang

The scavenger receptor class B type I gene can protect against atherosclerosis; a mononucleotidepolymorphism is associated with differences in blood lipid metabolism, postprandial serum lipidlevels, insulin resistance, coronary artery disease and familial hyperlipidemia. In this study, thescavenger receptor class B type I gene exon 1 G4A gene polymorphism in atherosclerotic cerebralinfarction patients, cerebral hemorrhage patients and normal controls was detected using thepolymerase chain reaction-restriction fragment length polymorphism method. The results showedthat the GA + AA genotype frequency of scavenger receptor class B type I gene G4A inatherosclerotic cerebral infarction patients was similar to that in cerebral hemorrhage patients andnormal controls; however, the A allele frequency was significantly lower than that in normal controls.The serum level of high-density lipoprotein cholesterol in patients with the scavenger receptor classB type I gene G4A GA + AA genotype was significantly higher, while the serum level of low-densitylipoprotein cholesterol was significantly lower than that in patients with the GG genotype, in both theatherosclerotic cerebral infarction and cerebral hemorrhage groups. The serum level of high-densitylipoprotein cholesterol in patients with the scavenger receptor class B type I gene G4A GA + AAgenotype was significantly higher, while the serum levels of low-density lipoprotein cholesterol andtotal cholesterol were significantly lower than those in normal controls with the GG genotype. Ourexperimental results suggest that the G4A polymorphism of the scavenger receptor class B type Igene is a possible predisposing risk factor for atherosclerotic cerebral infarction, and that it has noassociation with cerebral hemorrhage in the Han population in Hunan province of China. The Aallele is possibly associated with the metabolism of high-density and low-density lipoproteincholesterol.