根據(jù)一項(xiàng)研究,，自從2006年起在美國導(dǎo)致蜜蜂蜂巢毀滅的神秘的蜂群崩潰失調(diào)?。–CD）可能部分是由于破壞了基因翻譯的病毒造成的,。此前的一些研究發(fā)現(xiàn)了CCD與蜜蜂畸翅病毒與以色列急性麻痹病毒等病毒之間的聯(lián)系,，而其他一些研究提到了殺蟲劑的作用，但是這些研究都沒有確定一個(gè)直接的原因,。
May Berenbaum及其同事分析了蜜蜂腸道的基因表達(dá),。蜜蜂的腸道是殺蟲劑解毒和免疫防御的主要地點(diǎn),。這組科學(xué)家比較了美國東海岸和西海岸CCD蜂群的蜜蜂和來自健康蜂巢的蜜蜂,，結(jié)果發(fā)現(xiàn)CCD蜜蜂擁有大量不尋常的核糖體RNA片段,。由于核糖體屬于細(xì)胞制造蛋白質(zhì)的一部分，這項(xiàng)發(fā)現(xiàn)提示CCD蜂群的蜜蜂的蛋白質(zhì)生產(chǎn)很可能受到了損害。這組科學(xué)家提出,，這些片斷可能來自于已經(jīng)確定與CCD有關(guān)聯(lián)的病毒的多重感染,，這些病毒以核糖體為目標(biāo),。這組作者說,，無論病毒過量是不是蜂群崩潰的根本原因，測試核糖體片段可能成為CCD的一個(gè)有用的診斷標(biāo)記,。（生物谷Bioon.com）
生物谷推薦原始出處：
PNAS August 24, 2009, doi: 10.1073/pnas.0906970106
Changes in transcript abundance relating to colony collapse disorder in honey bees (Apis mellifera)
Reed M. Johnsona,1, Jay D. Evansb, Gene E. Robinsona and May R. Berenbauma,2
aDepartment of Entomology, University of Illinois at Urbana-Champaign, Urbana, IL 61801; and
bBee Research Laboratory, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD 20705
Colony collapse disorder (CCD) is a mysterious disappearance of honey bees that has beset beekeepers in the United States since late 2006. Pathogens and other environmental stresses, including pesticides, have been linked to CCD, but a causal relationship has not yet been demonstrated. Because the gut acts as a primary interface between the honey bee and its environment as a site of entry for pathogens and toxins, we used whole-genome microarrays to compare gene expression between guts of bees from CCD colonies originating on both the east and west coasts of the United States and guts of bees from healthy colonies sampled before the emergence of CCD. Considerable variation in gene expression was associated with the geographical origin of bees, but a consensus list of 65 transcripts was identified as potential markers for CCD status. Overall, elevated expression of pesticide response genes was not observed. Genes involved in immune response showed no clear trend in expression pattern despite the increased prevalence of viruses and other pathogens in CCD colonies. Microarray analysis revealed unusual ribosomal RNA fragments that were conspicuously more abundant in the guts of CCD bees. The presence of these fragments may be a possible consequence of picorna-like viral infection, including deformed wing virus and Israeli acute paralysis virus, and may be related to arrested translation. Ribosomal fragment abundance and presence of multiple viruses may prove to be useful diagnostic markers for colonies afflicted with CCD.
