生物谷報(bào)道：過去普遍的看法,，毛囊一旦受損,，可能永遠(yuǎn)無法修復(fù)。 但日前,，在老鼠表皮上幫助培植新毛發(fā)細(xì)胞的科學(xué)家表示,，人類脫發(fā)并非是不可逆的。
美國(guó)賓夕法尼亞大學(xué)的一個(gè)研究小組在《自然》雜志上報(bào)告說,，實(shí)際上可以利用一種單基因促使毛發(fā)再生,。英國(guó)的一位專家表示，這項(xiàng)研究可能在輔助傷口愈合技術(shù)方面有著更為重要的意義,。人們普遍認(rèn)為,，在人的一生中不會(huì)再長(zhǎng)出新的毛囊。賓夕法尼亞州的這個(gè)研究小組發(fā)現(xiàn),，在傷口愈合方面起著重要作用的wnt基因好像可以促進(jìn)新毛囊的生長(zhǎng),。
研究人員表示,，他們的發(fā)現(xiàn)不僅為禿頂?shù)闹委煷蜷_了一扇窗戶,，而且對(duì)傷口愈合和再生方面的治療也起著重要的作用。來自布拉德福大學(xué)的英國(guó)專家德斯·托賓教授說：“這篇報(bào)告提供了有力的證據(jù),，說明皮膚擁有超強(qiáng)的再生能力,，不僅僅是先前就已經(jīng)知道的修復(fù)能力。這份觀察報(bào)告的隱含意義有很多,，但它或許主要是為了給我們講述成人干細(xì)胞的再生能力,，以及它在再生醫(yī)學(xué)和傷口愈合方面的應(yīng)用。”
原始出處:
Nature 447, 316-320 (17 May 2007) | doi:10.1038/nature05766; Received 30 August 2006; Accepted 20 March 2007
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
Mayumi Ito1, Zaixin Yang1, Thomas Andl1, Chunhua Cui1, Noori Kim1, Sarah E. Millar1 & George Cotsarelis1
Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Correspondence to: George Cotsarelis1 Correspondence and requests for materials should be addressed to G.C. (Email: [email protected]).
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Abstract
The mammalian hair follicle is a complex 'mini-organ' thought to form only during development1; loss of an adult follicle is considered permanent. However, the possibility that hair follicles develop de novo following wounding was raised in studies on rabbits2, 3, mice4 and even humans fifty years ago5. Subsequently, these observations were generally discounted because definitive evidence for follicular neogenesis was not presented6. Here we show that, after wounding, hair follicles form de novo in genetically normal adult mice. The regenerated hair follicles establish a stem cell population, express known molecular markers of follicle differentiation, produce a hair shaft and progress through all stages of the hair follicle cycle. Lineage analysis demonstrated that the nascent follicles arise from epithelial cells outside of the hair follicle stem cell niche, suggesting that epidermal cells in the wound assume a hair follicle stem cell phenotype. Inhibition of Wnt signalling after re-epithelialization completely abrogates this wounding-induced folliculogenesis, whereas overexpression of Wnt ligand in the epidermis increases the number of regenerated hair follicles. These remarkable regenerative capabilities of the adult support the notion that wounding induces an embryonic phenotype in skin, and that this provides a window for manipulation of hair follicle neogenesis by Wnt proteins. These findings suggest treatments for wounds, hair loss and other degenerative skin disorders.
