生物谷報道：一項新的研究顯示,，幼年時期的癌癥可能與胎記有關(guān)。美國明尼蘇達(dá)州立大學(xué)的Julie A. Ross博士表示：“胎記代表的可能是胎兒在出生前發(fā)育情況受到改變,，這種現(xiàn)象會提高形成癌癥的風(fēng)險,。此研究發(fā)表于醫(yī)學(xué)期刊Pediatrics。”
研究人員調(diào)查的資料來源為出生于1959到1966年的49,503位兒童,，若有胎記的兒童,，在其出生后一年內(nèi)就被詳載于文件中，這些胎記的型式包括：鮮紅斑痣（port-wine stains）、色素痣（pigmented moles）,、草莓胎記（strawberry birthmarks）以及咖啡牛奶斑(Cafe-au-lait spot)等,。其中共有2,505位兒童在文件中有記載胎記記錄，47位在八歲前被診斷出癌癥的兒童中有7位為有胎記記錄,。
把所有的癌癥都統(tǒng)計在內(nèi),，有胎記的人在幼童時期得到癌癥的機(jī)會大約高三倍，但對于會產(chǎn)生何種癌癥則沒有特異性,。Ross博士的研究團(tuán)隊表示：“此調(diào)查中,，由于得到癌癥的人數(shù)過少，所以此推論也可能是機(jī)率,。不過,，研究人員仍希望這項調(diào)查結(jié)果，能讓大家關(guān)心胎記的產(chǎn)生可能也是幼童時期造成癌癥的原因之一,。”
原始出處:
PEDIATRICS,， Vol. 119 No. 5 May 2007, pp. e1088-e1093 (doi:10.1542/peds.2006-2315)
Childhood Cancer and Birthmarks in the Collaborative Perinatal Project
Kimberly J. Johnson, MPHa, Logan G. Spector, PhDa, Mark A. Klebanoff, MD, MPHb and Julie A. Ross, PhDa
a Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota
b National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
OBJECTIVE. Three previous retrospective studies noted a positive association between birthmarks and childhood cancer. The objective of this study was to determine whether the incidence of cancer is increased in children with birthmarks relative to those without birthmarks using data from the Collaborative Perinatal Project cohort, a large, prospective study.
METHODS. Our study population comprised 49503 US children who were born between 1959 and 1968. Birthmarks were documented as definite or suspected during the first year through history or medical examinations and included hemangiomas (port-wine, strawberry, or cavernous), pigmented nevi, lymphangiomas, and café-au-lait spots. The association between birthmarks and childhood cancer was determined using Cox proportional hazards regression.
RESULTS. In the Collaborative Perinatal Project, 2505 individuals had a documented definite or suspected birthmark, including 7 of 47 children who developed cancer. Birthmarks were associated with a significant increase in the risk for cancer. There was a slight attenuation of the risk estimate when cases that were diagnosed in the first year of life were excluded. No specific childhood malignancies were notably affected by birthmarks.
CONCLUSIONS. Although this study was based on a small number of cases, we found birthmarks to be in excess in children who received a diagnosis of cancer using prospective data. These findings provide additional support for the possibility of a shared etiology between birthmarks and childhood cancer that could offer insight into the pathogenesis of pediatric malignancy.
Key Words: birthmarks • childhood cancer • etiology • risk factors
Abbreviations: BWS—Beckwith-Wiedemann syndrome • NF1—neurofibromatosis type I • ALL—acute lymphoblastic leukemia • CPP—Collaborative Perinatal Project • HR—hazard ratio • CI—confidence interval • SES—socioeconomic status • AML—acute myelogenous leukemia • IGF—insulin-like growth factor
