生物谷報道：美國研究人員的研究結(jié)果顯示，維生素D含量低的人群罹患心臟病,、心力衰竭及中風(fēng)的風(fēng)險較高,。
據(jù)美國《循環(huán)》（Circulation）月刊最近公布的一項研究結(jié)果，研究人員耗時5年跟蹤調(diào)查了1739名平均年齡為59歲的研究對象,，他們均沒有心血管病史,。研究人員定期給他們采血，測維生素D含量,。
研究結(jié)果顯示,，即使將糖尿病、高膽固醇和高血壓等這些易導(dǎo)致心血管疾病的因素全部考慮進(jìn)去,，與維生素D含量高的人群相比,，含量低的人群患心臟病、心力衰竭和中風(fēng)的風(fēng)險要高60%,，如果還同時患有高血壓的話,，這種風(fēng)險將加倍。
研究人員說,，這一發(fā)現(xiàn)令人振奮,，但現(xiàn)在就說攝入維生素D便可以降低心臟病等風(fēng)險還為時尚早，暫時也無法建議人們出于此目的而攝取維生素D,。
專家建議,，為改善缺乏維生素D的癥狀，人們可采用常曬太陽,、食用牛奶和多脂肪魚類等手段,。一周曬3次太陽，每次10到15分鐘，就能獲取所需要的維生素D量,。
另據(jù)英國科學(xué)家的研究結(jié)果,，維生素D吸收較多的人，衰老速度較緩慢,。人體90%的維生素D通過日照獲得,，因此維生素D又被稱為“陽光維生素”。較常接受日照的人比避免日照的人生理機(jī)能年輕5歲,。（來源：新華網(wǎng)）
（《循環(huán)》（Circulation）,，doi: 10.1161/CIRCULATIONAHA.107.706127，Thomas J. Wang, Ramachandran S. Vasan）
生物谷推薦原始出處：
Circulation
Published Online
on January 7, 2008
Submitted on April 4, 2007
Accepted on November 2, 2007
Vitamin D Deficiency and Risk of Cardiovascular Disease
Thomas J. Wang MD*, Michael J. Pencina PhD, Sarah L. Booth PhD, Paul F. Jacques DSc, Erik Ingelsson MD, PhD, Katherine Lanier BS, Emelia J. Benjamin MD, MSc, Ralph B. D’Agostino PhD, Myles Wolf MD, MMSc, and Ramachandran S. Vasan MD
From the Framingham Heart Study, Framingham, Mass (T.J.W., M.J.P., E.I., K.L., E.J.B., R.B.D., R.S.V.); Cardiology Division (T.J.W.) and Renal Division (M.W.), Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Statistics and Consulting Unit, Department of Mathematics (M.J.P., R.B.D.), Boston University, Boston, Mass; Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging (S.L.B., P.F.J.), Tufts University, Boston, Mass; and Sections of Cardiology and Preventive Medicine (E.J.B., R.S.V.), Boston Medical Center, Boston University School of Medicine, Boston, Mass.
* To whom correspondence should be addressed. E-mail: [email protected] .
Background—Vitamin D receptors have a broad tissue distribution that includes vascular smooth muscle, endothelium, and cardiomyocytes. A growing body of evidence suggests that vitamin D deficiency may adversely affect the cardiovascular system, but data from longitudinal studies are lacking.
Methods and Results—We studied 1739 Framingham Offspring Study participants (mean age 59 years; 55% women; all white) without prior cardiovascular disease. Vitamin D status was assessed by measuring 25-dihydroxyvitamin D (25-OH D) levels. Prespecified thresholds were used to characterize varying degrees of 25-OH D deficiency (<15 ng/mL, <10 ng/mL). Multivariable Cox regression models were adjusted for conventional risk factors. Overall, 28% of individuals had levels <15 ng/mL, and 9% had levels <10 ng/mL. During a mean follow-up of 5.4 years, 120 individuals developed a first cardiovascular event. Individuals with 25-OH D <15 ng/mL had a multivariable-adjusted hazard ratio of 1.62 (95% confidence interval 1.11 to 2.36, P=0.01) for incident cardiovascular events compared with those with 25-OH D 15 ng/mL. This effect was evident in participants with hypertension (hazard ratio 2.13, 95% confidence interval 1.30 to 3.48) but not in those without hypertension (hazard ratio 1.04, 95% confidence interval 0.55 to 1.96). There was a graded increase in cardiovascular risk across categories of 25-OH D, with multivariable-adjusted hazard ratios of 1.53 (95% confidence interval 1.00 to 2.36) for levels 10 to <15 ng/mL and 1.80 (95% confidence interval 1.05 to 3.08) for levels <10 ng/mL (P for linear trend=0.01). Further adjustment for C-reactive protein, physical activity, or vitamin use did not affect the findings.
Conclusions—Vitamin D deficiency is associated with incident cardiovascular disease. Further clinical and experimental studies may be warranted to determine whether correction of vitamin D deficiency could contribute to the prevention of cardiovascular disease.
Key words: cardiovascular diseases • risk factors • vitamin D
